高危食管静脉曲张患者一级预防食管静脉曲张出血（OVB）——CAVARLY更强！！

IF 23 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pub Date : 2024-11-28 DOI:10.1136/gutjnl-2024-334130

Harsh Vardhan Tevethia, Apurva Pande, Rajan Vijayaraghavan, Guresh Kumar, Shiv Kumar Sarin

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引用次数: 0

摘要

我们要感谢Dunne等人对我们的工作感兴趣他们主要关注的是，尽管与其他组相比，联合组的死亡率和食管静脉曲张出血（OVB）较低，但两组中肝脏相关事件（LREs）的发生率相似，包括进展为腹水。其次，与其他组相比，卡维地洛组的ovb发生率和出血相关死亡率更高。我们要强调的是，在我们的研究中，我们没有发现卡维地洛组和联合用药组在降低肝静脉压梯度（HVPG）方面有任何显著差异。后者已被证明与各种LREs及其进展相关降价10%或…

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Primary prophylaxis in patients with high risk oesophageal varices to prevent oesophageal variceal bleeding (OVB)—The CAVARLY is stronger together!!

We would like to thank Dunne et al 1 for their interest in our work.2 Their main concerns are that the rates of liver-related events (LREs) including progression to ascites were similar in both the groups in spite of lower mortality and oesophageal variceal bleed (OVB) in the combination arm as compared with the other arms. Second, the rates of OVBs and the bleed-related mortality were higher in the carvedilol arm as compared with the other arms. We would like to emphasise that in our study, we did not find any significant difference between the carvedilol arm and the combination arm in the reduction of hepatic venous pressure gradient (HVPG). The latter has been shown to correlate with various LREs and their progression.3 The reduction by 10% or …

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来源期刊

Gut 医学-胃肠肝病学

CiteScore

45.70

自引率

2.40%

发文量

284

审稿时长

1.5 months

期刊介绍： Gut is a renowned international journal specializing in gastroenterology and hepatology, known for its high-quality clinical research covering the alimentary tract, liver, biliary tree, and pancreas. It offers authoritative and current coverage across all aspects of gastroenterology and hepatology, featuring articles on emerging disease mechanisms and innovative diagnostic and therapeutic approaches authored by leading experts. As the flagship journal of BMJ's gastroenterology portfolio, Gut is accompanied by two companion journals: Frontline Gastroenterology, focusing on education and practice-oriented papers, and BMJ Open Gastroenterology for open access original research.