英夫利昔单抗治疗后视网膜中央静脉闭塞的年轻患者溃疡性结肠炎。

JPGN reports Pub Date : 2024-08-26 eCollection Date: 2024-11-01 DOI:10.1002/jpr3.12122
Joana Victor Lage, Joana Filipe Ribeiro, Margarida Vicente-Ferreira, Joana Rodrigues Araújo, Isabel Pais, Céu Espinheira, Eunice Trindade
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引用次数: 0

摘要

炎症性肠病(IBD)是一种慢性疾病,以胃肠道反复炎症为特征。虽然IBD管理的主要重点是控制胃肠道症状,但IBD也会增加血栓栓塞并发症的风险。肿瘤坏死因子α (TNF-α)抑制剂,即英夫利昔单抗,在多种慢性炎症性疾病(如IBD)的治疗中越来越普遍。然而,最近的研究表明英夫利昔单抗治疗与血栓形成风险增加之间存在关联。我们报告一个不寻常的情况下视网膜静脉血栓形成的患者溃疡性结肠炎(UC),发生在英夫利昔单抗输注。本病例强调了IBD患者使用英夫利昔单抗时需要保持警惕,特别是那些有其他血栓危险因素的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Central retinal vein occlusion after infliximab therapy in a young patient with ulcerative colitis.

Inflammatory bowel disease (IBD) is a chronic condition, characterized by recurrent inflammation of the gastrointestinal tract. While the primary focus of IBD management consists in controlling gastrointestinal symptoms, IBD also presents an increased risk of thromboembolic complications. Tumor necrosis factor alpha (TNF-α) inhibitors, namely infliximab, have become increasingly common in the management of multiple chronic inflammatory diseases such as IBD. However, recent studies have shown an association between treatment with infliximab and an increased thrombotic risk. We report an unusual case of retinal vein thrombosis in a patient with ulcerative colitis (UC) that occurred during infliximab infusion. This case highlights the need to remain vigilant when administering infliximab to individuals with IBD, particularly those with additional risk factors for thrombosis.

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