糖尿病对心肌病功能障碍中紧密连接的影响。

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2024-07-30 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01469-5

Leila Chodari, Sina Fatehfar, Mahan Ahmadi, Vajihe Ghorbanzadeh

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引用次数: 0

摘要

糖尿病性心肌病是一种以糖尿病患者心室功能障碍为特征的疾病，不是由其他心脏疾病引起的。它与左心室肥厚、代谢紊乱和氧化应激等因素有关。紧密连接在细胞之间形成屏障，在糖尿病的血管并发症中起作用。诸如claudin和occludens之类的蛋白质对紧密连接的结构和功能很重要。闭塞带蛋白（ZO）也参与紧密连接，其表达可能受到糖尿病的影响。本文就糖尿病对紧密连接的影响及ZO蛋白在糖尿病心血管功能障碍中的作用作一综述。

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The impact of diabetes on tight junctions in cardiomyopathy dysfunction.

Diabetic cardiomyopathy is a condition characterized by ventricular dysfunction in diabetic patients that is not caused by other cardiac ailments. It is associated with factors such as left ventricular hypertrophy, metabolic disturbances, and oxidative stress. Tight junctions, which form a barrier between cells, play a role in the vascular complications of diabetes. Proteins such as claudins and occludens are important for the structure and function of tight junctions. Zona occludens (ZO) proteins are also involved in tight junctions and their expression may be affected by diabetes. The review discusses the impact of diabetes on the tight junctions and the role of ZO proteins in diabetic cardiovascular dysfunction.

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.