从胶质细胞角度看脊髓损伤引起的神经性疼痛及其治疗

IF 3.6 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2024-11-28 DOI:10.1007/s10571-024-01517-x

Ying Ye, Xinjin Su, Jun Tang, Chao Zhu

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引用次数: 0

摘要

脊髓损伤（SCI）后，脊髓损伤部位上方、下方或下方会出现区域性神经病理性疼痛综合征，这些综合征被认为涉及不同的途径；然而，它们可能共享有缺陷的神经胶质细胞系统。脊髓损伤后的神经性疼痛是由神经胶质细胞、神经元末梢的异位发射及其细胞内和细胞外信号机制引起的。其中一种机制是当以前无痛的刺激在受伤后变得有痛。这将表现出异痛症的症状。另一种机制是神经胶质细胞释放物质，即使在远离损伤部位的区域也能保持背角神经元的敏感性。在此，我们回顾了 SCI 诱导的神经病理性疼痛（SCI-NP）的模型和鉴定、与神经胶质细胞有关的 SCI-NP 机制以及 SCI-NP 的治疗方法。

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Neuropathic Pain Induced by Spinal Cord Injury from the Glia Perspective and Its Treatment.

Regional neuropathic pain syndromes above, at, or below the site of spinal damage arise after spinal cord injury (SCI) and are believed to entail distinct pathways; nevertheless, they may share shared defective glial systems. Neuropathic pain after SCI is caused by glial cells, ectopic firing of neurons endings and their intra- and extracellular signaling mechanisms. One such mechanism occurs when stimuli that were previously non-noxious become so after the injury. This will exhibit a symptom of allodynia. Another mechanism is the release of substances by glia, which keeps the sensitivity of dorsal horn neurons even in regions distant from the site of injury. Here, we review, the models and identifications of SCI-induced neuropathic pain (SCI-NP), the mechanisms of SCI-NP related to glia, and the treatments of SCI-NP.

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.