免疫-基质相互作用塑造健康和疾病中的肾功能

IF 28.6 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Nephrology Pub Date : 2024-11-28 DOI:10.1038/s41581-024-00911-4

Chirag Raparia, Anne Davidson

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引用次数: 0

摘要

新的研究揭示了髓质巨噬细胞的一种新的平衡清除功能，揭示了先天性淋巴细胞和上皮细胞在协调炎症和纤维化中的作用，并表明克隆造血会影响炎症对损伤的反应程度。这些发现提出了预防与老化和损伤相关的肾功能障碍的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immune–stromal interplay shapes kidney function in health and disease

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Immune–stromal interplay shapes kidney function in health and disease

New studies have revealed a novel homeostatic clearance function for medullary macrophages, unveiled roles for innate lymphoid cells and epithelial cells in orchestrating inflammation and fibrosis, and shown that clonal haematopoiesis influences the magnitude of inflammation in response to injury. These discoveries suggest therapeutic strategies to prevent kidney dysfunction associated with ageing and injury.

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来源期刊

Nature Reviews Nephrology 医学-泌尿学与肾脏学

CiteScore

39.00

自引率

1.20%

发文量

127

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.