磷苯碱催化的伸缩三组分反应，涉及缺电子烯的 1,1-二官能化

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-11-28 DOI:10.1039/d4cc05169f

Azusa Kondoh, Sho Yamaguchi, Masahiro Terada

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引用次数: 0

摘要

磷苯碱 P2-tBu 高效催化了亚磷酸二乙酯、肉桂腈衍生物和 N-Boc 亚胺的伸缩三组分反应，以高非对映选择性的方式提供了具有四取代碳的β-氨基膦酸盐。该反应涉及鲜为人知的缺电子烯的 1,1-二官能化，为布氏碱催化下的三组分反应提供了一种新形式。

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Phosphazene base-catalyzed telescopic three-component reaction involving 1,1-difunctionalization of electron-deficient alkenes

Phosphazene base, P2-tBu, efficiently catalyzed the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and N-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner. The reaction involves the little-known 1,1-difunctionalization of an electron-deficient alkene, offering a new format for the three-component reaction under Brønsted base catalysis.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.