牛呼吸道合胞病毒与牛之间的相互作用:发病机制和免疫方面。

IF 3.8 3区 医学 Q2 VIROLOGY
Viruses-Basel Pub Date : 2024-11-08 DOI:10.3390/v16111753
Lariane da Silva Barcelos, Alexandra K Ford, Matheus Iuri Frühauf, Nadalin Yandra Botton, Geferson Fischer, Mayara Fernanda Maggioli
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引用次数: 0

摘要

牛呼吸道合胞病毒(BRSV)是牛的一种主要呼吸道病原体,与全球畜牧业息息相关。幼犊感染 BRSV 的情况最为严重,而且往往与紧张的管理事件有关。由于生产力下降、发病率、死亡率以及预防和治疗成本增加,该疾病造成了经济损失。作为同属的成员,牛和人的 RSV 具有高度的同源性,在基因组、传播、临床症状和流行病学方面都很相似。这种重叠为 "同一健康 "方法和转化研究提供了机会,并带来了双重益处;然而,针对 BRSV 的研究仍然相对缺乏,而对改进预防方法的不断探索也凸显了深入了解其免疫学特征的必要性。BRSV 采用了不同的宿主免疫逃避机制,这些机制干扰了对现有疫苗和自然感染的有效长期记忆反应。本综述对 BRSV 的免疫过程进行了最新描述,如参与 BRSV 感染的 PRRs 和信号通路、其致病性的各个方面以及病毒为挫败免疫反应而开发的逃避机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interactions Between Bovine Respiratory Syncytial Virus and Cattle: Aspects of Pathogenesis and Immunity.

Bovine respiratory syncytial virus (BRSV) is a major respiratory pathogen in cattle and is relevant to the livestock industry worldwide. BRSV is most severe in young calves and is often associated with stressful management events. The disease is responsible for economic losses due to lower productivity, morbidity, mortality, and prevention and treatment costs. As members of the same genus, bovine and human RSV share a high degree of homology and are similar in terms of their genomes, transmission, clinical signs, and epidemiology. This overlap presents an opportunity for One Health approaches and translational studies, with dual benefits; however, there is still a relative lack of studies focused on BRSV, and the continued search for improved prophylaxis highlights the need for a deeper understanding of its immunological features. BRSV employs different host-immunity-escaping mechanisms that interfere with effective long-term memory responses to current vaccines and natural infections. This review presents an updated description of BRSV's immunity processes, such as the PRRs and signaling pathways involved in BRSV infection, aspects of its pathogeny, and the evading mechanisms developed by the virus to thwart the immune response.

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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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