Jonida Kokiçi, Anucha Preechanukul, Helena Arellano-Ballestero, Frances Gorou, Dimitra Peppa
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引用次数: 0
摘要
自然杀伤(NK)细胞是一种先天性淋巴细胞,能利用多种机制对目标迅速做出反应。由于其功能特性,NK 细胞被认为参与了抗病毒和抗肿瘤免疫反应。虽然传统上人们知道 NK 细胞能做出非特异性的快速免疫反应,但近年来,具有适应性特征的记忆性 NK 细胞的概念得到了越来越多的认可。记忆性 NK 细胞会对病毒抗原和特定细胞因子组合等不同刺激做出反应。它们形成不同的群体,并伴随着转录、表观遗传和代谢重编程,从而形成独特的表型和功能属性。由于记忆 NK 细胞的功能、生物能谱和体内持久性得到了增强,多项临床试验正在对其疗效进行测试。NK 细胞的治疗潜力正被用于病毒感染,并在癌症领域得到更广泛的应用。在这篇综述中,我们总结了有关记忆 NK 细胞生成的研究现状,以及它们在病毒感染和癌症中的临床应用。
Emerging Insights into Memory Natural Killer Cells and Clinical Applications.
Natural killer (NK) cells are innate lymphocytes that can rapidly mount a response to their targets by employing diverse mechanisms. Due to their functional attributes, NK cells have been implicated in anti-viral and anti-tumour immune responses. Although traditionally known to mount non-specific, rapid immune responses, in recent years, the notion of memory NK cells with adaptive features has gained more recognition. Memory NK cells emerge in response to different stimuli, such as viral antigens and specific cytokine combinations. They form distinct populations, accompanied by transcriptional, epigenetic and metabolic reprogramming, resulting in unique phenotypic and functional attributes. Several clinical trials are testing the efficacy of memory NK cells due to their enhanced functionality, bioenergetic profile and persistence in vivo. The therapeutic potential of NK cells is being harnessed in viral infections, with wider applications in the cancer field. In this review, we summarise the current state of research on the generation of memory NK cells, along with their clinical applications in viral infection and cancer.
期刊介绍:
Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.