老年急性髓性白血病：从生物学新见解到靶向治疗。

IF 2.8 4区医学 Q2 ONCOLOGY

Current oncology Pub Date : 2024-10-24 DOI:10.3390/curroncol31110490

Pasquale Niscola, Valentina Gianfelici, Gianfranco Catalano, Marco Giovannini, Carla Mazzone, Nelida Ines Noguera, Paolo de Fabritiis

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引用次数: 0

摘要

急性髓性白血病（AML）是一种异质性血液相关肿瘤，由于老年人的身体状况、伴随的并发症、不良的疾病生物学特征以及是否适合诱导强化化疗和异基因干细胞移植等因素，该病的预后较差。最近对导致疾病发展和恶化的分子和生物因素的研究，使老年急性髓细胞性白血病患者的治疗方法取得了重大进展。这篇综述文章讨论了改变老年急性髓细胞性白血病治疗方法的最新生物和治疗进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies.

Acute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive chemotherapy and allogenic stem cells transplantation. Recent research into the molecular and biological factors contributing to disease development and progression has led to significant advancements in treatment approaches for older patients with AML. This review article discusses the latest biological and therapeutic developments that are transforming the management of AML in older adults.

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来源期刊

Current oncology ONCOLOGY-

CiteScore

3.30

自引率

7.70%

发文量

664

审稿时长

1 months

期刊介绍： Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.