成纤维细胞在人类疾病中的研究进展。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-11-20 DOI:10.3390/biom14111478

Xiaodong Li, Nana Li, Yujie Wang, Qixiang Han, Boshi Sun

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引用次数: 0

摘要

成纤维细胞源自胚胎间充质细胞，是疏松结缔组织中的主要细胞类型。作为细胞赖以生存的内部环境的主要成分，成纤维细胞在组织发育、伤口愈合和维持组织稳态方面发挥着至关重要的作用。此外，成纤维细胞还参与了多种病理过程，如纤维化、癌症和一些炎症性疾病。在这篇综述中，我们分析了成纤维细胞的最新研究进展，总结了成纤维细胞的生物学特征和生理功能，深入探讨了成纤维细胞在疾病发病机制中的作用，并探讨了成纤维细胞相关疾病的治疗方法。

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Research Progress of Fibroblasts in Human Diseases.

Fibroblasts, which originate from embryonic mesenchymal cells, are the predominant cell type seen in loose connective tissue. As the main components of the internal environment that cells depend on for survival, fibroblasts play an essential role in tissue development, wound healing, and the maintenance of tissue homeostasis. Furthermore, fibroblasts are also involved in several pathological processes, such as fibrosis, cancers, and some inflammatory diseases. In this review, we analyze the latest research progress on fibroblasts, summarize the biological characteristics and physiological functions of fibroblasts, and delve into the role of fibroblasts in disease pathogenesis and explore treatment approaches for fibroblast-related diseases.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.