儿童失神性癫痫的全程功率演变:多频率脑磁图研究

IF 2.7 3区 医学 Q2 CLINICAL NEUROLOGY
Minghao Li , Xinyi Zhou , Yingfan Wang, Jing Lu, Yinjie Zhu, Peilin Jiang, Ke Hu, Xiaoshan Wang
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引用次数: 0

摘要

目的本研究利用多频脑磁图(MEG)分析探讨儿童失神性癫痫(CAE)全过程的神经磁活动变化。我们的目的是揭示潜在的神经生理学机制,并确定具有潜在临床应用价值的功能信号靶点。方法我们招募了 37 名对药物无反应的 CAE 患儿,并使用 CTF-275 通道 MEG 系统收集了 62 次发作和发作间期的脑磁图(MEG)数据。对发作过程进行了时间统一分割,并进行了动态频带分析。结果2-60 Hz 的全脑磁源功率变化在很大程度上与尖峰和波放电(SWD)的进展相平行,而 60-90 Hz 的功率在癫痫发作期间受到抑制。α波段(8-12赫兹)活动在癫痫发作开始时迅速失去枕叶优势,同时额叶α活动升高。这种额叶α主导活动持续整个发作期,并在终止时恢复到枕叶主导活动。Beta 和 gamma1 波段(15-59 Hz)的活动在 SWDs 停止前明显下降。结论对 CAE 整个过程中神经磁信号的频谱功率分析发现了特定频率依赖性特征变化,其中阿尔法波段(8-12 Hz)活动的分布与失神表现密切相关,而贝塔波段(15-29 Hz)功率的下降会诱发癫痫发作终止。此外,发作期 SWDs 功率可作为癫痫严重程度的神经影像学指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Whole-course power evolution in childhood absence epilepsy: A multi-frequency magnetoencephalography study

Objective

This study explores the whole-course neuromagnetic activity changes in childhood absence epilepsy (CAE) using multifrequency magnetoencephalogram (MEG) analysis. We aim to uncover the underlying neurophysiological mechanisms and identify functional signal targets with potential clinical applications.

Methods

We recruited 37 drug-naive children with CAE and collected magnetoencephalography (MEG) data from 62 seizures and interictal periods using a CTF-275 channel MEG system. The seizure course was segmented with temporal unification and subjected to dynamic frequency band analysis. Minimum norm estimation combined with Welch's method was employed for spectral power calculation, followed by correlation analysis between power and seizure duration.

Results

Whole-brain magnetic source power changes in 2–60 Hz largely paralleled the progression of spike and wave discharges (SWDs), while power in 60–90 Hz was suppressed during seizures. Alpha band (8–12 Hz) activity showed a prompt loss of occipital dominance at seizure onset, with concurrent elevation in frontal alpha activity. This frontal alpha dominance persisted throughout the ictal period and reverted to occipital dominance at termination. Beta and gamma1 band (15–59 Hz) activity characteristically declined before SWDs cessation. The power of SWDs during ictal period was negatively correlated with seizure duration.

Conclusion

Spectral power analysis of neuromagnetic signals throughout CAE process identifies specific frequency-dependent characteristic changes, among which, the distribution of alpha band (8–12 Hz) activity is closely related to absence manifestations, beta band (15–29 Hz) power decline induces seizure termination. Additionally, ictal SWDs power can serve as a neuroimaging indicator of epilepsy severity.
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来源期刊
Seizure-European Journal of Epilepsy
Seizure-European Journal of Epilepsy 医学-临床神经学
CiteScore
5.60
自引率
6.70%
发文量
231
审稿时长
34 days
期刊介绍: Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.
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