利用五配位硅中间体的扩环反应合成二苯并氧西来平

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-11-27 DOI:10.1002/adsc.202401125

Keigo WATANABE, Mutsuki Sato, Tsunayoshi Takehara, Kaori ASANO, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Makoto SAKO, Mitsuhiro Arisawa

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引用次数: 0

摘要

二苯并恶嗪是合成化学和药物化学中的重要骨架。在这里，我们成功地获得了比传统方法更高的产率，并首次阐明了环状五配位硅中间体在扩环反应中两个芳香环的重排趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of Dibenzoxasilepine Using Ring Expansion Reaction of a Pentacoordinate Silicon Intermediate

Dibenzoxasilepine is an important skeleton in both synthetic and medicinal chemistry. Here, we have succeeded in obtaining it in higher yield than the conventional method, elucidating for the first time the rearrangement tendency of the two aromatic rings during the ring expansion reaction on the cyclic pentacoordinate silicon intermediate.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.