手部骨关节炎的肌肉注射甲基强的松龙:一项回顾性队列研究。

IF 2.1 Q3 RHEUMATOLOGY
Rheumatology Advances in Practice Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI:10.1093/rap/rkae136
Merel Hartog, Jelle van Berkel, Bart J F Van den Bemt, Cornelia H M van den Ende, Calin D Popa
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引用次数: 0

摘要

目的:探讨与手部 OA 肌肉注射甲基强的松龙(MP)治疗反应相关的患者特征:探讨与手部 OA 患者对肌肉注射甲基强的松龙(MP)治疗反应相关的患者特征:我们进行了一项探索性的单中心回顾性研究。研究纳入了 2016 年 7 月至 2021 年 6 月期间在我院门诊就诊、临床诊断为手部 OA 并至少接受过一次 MP 肌肉注射的患者。临床数据,包括实验室和放射学结果,均从电子病历(EPR)中获取。根据电子病历中的自由文本,患者报告了对 MP 的反应以及注射后头 6 个月的反应持续时间。反应分为三类:无反应或症状恶化、反应一般和反应良好。反应持续时间分为短期(结果:对 262 名手部 OA 患者(76% 为女性)的数据进行了分析。150名患者(57.2%)反应良好。在反应一般的患者中,162 名患者(80.6%)的反应持续时间≥2 周。单变量回归分析表明,CRP 水平与良好反应相关[几率比 1.08(95% CI 1.00,1.17)]。然而,多变量回归分析表明两者之间没有统计学意义:在这项回顾性研究中,半数以上的手部 OA 患者对肌肉注射 MP 有良好反应。低度炎症的存在与这种疗法的反应之间可能存在的关系值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intramuscular methylprednisolone in hand osteoarthritis: a retrospective cohort study.

Objectives: To explore patient characteristics associated with response to intramuscular methylprednisolone (MP) therapy in hand OA.

Methods: We performed an exploratory monocentric retrospective study. Patients with a clinical diagnosis of hand OA who visited our outpatient clinic between July 2016 and June 2021 and received at least once an intramuscular MP injection were included. Clinical data, including laboratory and radiologic results, were retrieved from electronic patient records (EPRs). Patients' reported response to MP and its duration in the first 6 months after injection was based on free text from the EPRs. Response was categorized into three groups: no response or worsening of symptoms, modest response and good response. Duration of response was categorized as short-term (<2 weeks) or long-term (≥2 weeks). Multivariable logistic regression models were performed to determine factors associated with good response to therapy with MP.

Results: Data from 262 hand OA patients (76% female) were analysed. A good response was experienced by 150 patients (57.2%). Among those with modest-good response, the perceived response of 162 patients (80.6%) lasted ≥2 weeks. Univariate regression analysis indicated that the level of CRP was associated with good response [odds ratio 1.08 (95% CI 1.00, 1.17)]. However, multivariate regression analysis showed no statistically significant associations.

Conclusion: In this retrospective study, more than half of hand OA patients displayed good response to intramuscular MP administration. The possible relation between the presence of low-grade inflammation and the response to this therapy warrants further investigation.

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来源期刊
Rheumatology Advances in Practice
Rheumatology Advances in Practice Medicine-Rheumatology
CiteScore
3.60
自引率
3.20%
发文量
197
审稿时长
11 weeks
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