治疗严重哮喘的生物药物：了解致病异质性和内型的意义。

IF 15.1 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Annual review of medicine Pub Date : 2024-11-25 DOI:10.1146/annurev-med-070323-103158

Richard P Ramonell, Marc C Gauthier, Anuradha Ray, Sally E Wenzel

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引用次数: 0

摘要

哮喘是一种慢性气道炎症性疾病，其表型异质性早已众所周知。哮喘的表型研究已使疾病的发病机理得到了更好的描述，但还需要进一步的工作来将现有的治疗方法与疾病的内型配对。本综述讨论了靶向通路的生物学特性以及针对这些通路的生物疗法的疗效。其中包括哮喘临床试验结果以及相关疾病的试验结果。然后，本综述分析了生物制剂如何帮助了解哮喘复杂的免疫生物学并进一步指导其使用，同时确定了未来的研究领域。

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Biologic Medications for Severe Asthma: Implications for Understanding Pathogenic Heterogeneity and Endotypes.

Asthma is a chronic inflammatory disease of the airways long known for phenotypic heterogeneity. Phenotyping studies in asthma have led to a better characterization of disease pathogenesis, yet further work is needed to pair available treatments with disease endotypes. In this review, the biology of targeted pathways is discussed along with the efficacy of biologic therapies targeting those pathways. Results of asthma clinical trials are included, as well as results of trials in related diseases. This review then analyzes how biologics help to inform the complex immunobiology of asthma and further guide their use while identifying areas for future research.

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来源期刊

Annual review of medicine 医学-医学：内科

CiteScore

24.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.