在临床前阿尔茨海默氏症患者中，局部小脑代谢的升高可抵御认知能力的下降

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-11-26 DOI:10.1002/alz.14385

Elouise A. Koops, Joyita Dutta, Bernard J. Hanseeuw, J. Alex Becker, Maxime Van Egroo, Prokopis C. Prokopiou, Julie C. Price, Steven E. Arnold, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs

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引用次数: 0

摘要

脑室（LC）代谢周转的改变与阿尔茨海默病（AD）的病理和认知障碍有关。然而，这些变化在不同疾病阶段的演变及其功能相关性仍然未知。

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Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease

Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.