对沙特阿拉伯四肢软组织肉瘤的发病率、人口统计学特征和生存结果进行描述性分析。

IF 3.8 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Wazzan Aljuhani, Abdullah Alanazi, Eyad Alshehri, Mohammed K Alageel, Emad Masuadi, Mostafa Zolaly, Abdulrahman Bobsait
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引用次数: 0

摘要

软组织肉瘤是一种不常见、侵袭性强、组织学异质性的恶性肿瘤。软组织肿瘤类型有不同的年龄和解剖部位分布。本研究旨在评估沙特阿拉伯王国四肢软组织肉瘤的患病率和发病率,以促进早期诊断和干预。这项回顾性研究纳入了 2006 年 1 月至 2015 年 12 月期间确诊为四肢和骨盆原发性软组织肉瘤的所有患者。数据来自沙特癌症登记处。数字变量报告了均值和置信区间,分类变量报告了频率和百分比。卡方检验和方差分析用于检验分类数字变量之间的关联。考克斯回归分析用于确定每种肉瘤类型的危险比。在659名患者中,145人(22%)年龄在19-30岁之间,365人(55.4%)为男性,411人(62.4%)患有下肢肉瘤。大多数肿瘤(54.3%)是局部性的。肉瘤的发病率从每百万人中 2 例到 2.9 例不等(平均为每百万人中 2.4 例)。此外,脂肪肉瘤是最常见的诊断病例(135 例;20.5%),其次是未分化多形性肉瘤(87 例;13.2%)。沙特阿拉伯王国的软组织肉瘤发病率低于西方国家。不过,软组织肉瘤亚型的分布与其他国家相似。本研究中的存活率突出表明,有必要继续开展研究并采取有针对性的干预措施,以改善软组织肉瘤患者的预后,尤其是那些亚型更具侵袭性的患者,如非特殊类型肉瘤和横纹肌肉瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Descriptive analysis of incidence, demographic characteristics, and survival outcomes of soft-tissue sarcoma of the extremities in Saudi Arabia.

Soft-tissue sarcomas are uncommon, aggressive, and histologically heterogeneous, malignant tumors. Soft-tissue tumor types have different age and anatomical site distributions. This study aimed to assess the prevalence and incidence of soft-tissue sarcomas of the extremities to facilitate early diagnosis and intervention in the Kingdom of Saudi Arabia. This retrospective study included all patients diagnosed with primary soft-tissue sarcomas of the extremities and pelvis between January 2006 and December 2015. The data were obtained from the Saudi Cancer Registry. Means and confidence intervals were reported for numerical variables, whereas the frequencies and percentages were reported for categorical variables. The chi-squared test and analysis of variance were used to test the associations between categorical numerical variables. Cox regression analysis was used to determine the hazard ratios for each sarcoma type. Of the 659 patients, 145 (22%) were aged 19-30 years, 365 (55.4%) were men, and 411 (62.4%) had lower limb sarcoma. Most of the tumors (54.3%) were localized. The incidence of sarcoma ranged from 2 to 2.9 cases per one million (average, 2.4 cases per one million). Moreover, liposarcoma was the most commonly diagnosed (n = 135; 20.5%), followed by undifferentiated pleomorphic sarcoma (n = 87; 13.2%). The incidence of soft-tissue sarcomas in the Kingdom of Saudi Arabia were lower than those in Western countries. However, the distribution of soft-tissue sarcoma subtypes was similar to those in other countries. The survival rates in this study highlight the need for continued research and targeted interventions to improve the outcomes of patients with soft-tissue sarcomas, especially those with more aggressive subtypes, such as sarcoma not otherwise specified and rhabdomyosarcoma.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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