间充质干细胞:女性健康的守护者

IF 3.4 3区 环境科学与生态学 Q3 CELL & TISSUE ENGINEERING
Regenerative Therapy Pub Date : 2024-11-08 eCollection Date: 2024-06-01 DOI:10.1016/j.reth.2024.10.011
Guanwen Gao, Li Li, Changling Li, Degao Liu, Yunfei Wang, Changzhong Li
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引用次数: 0

摘要

间充质干细胞(MSCs)因其多向分化潜能、免疫调节能力和自我更新能力而受到越来越多的关注。近年来,间充质干细胞在再生医学和组织工程学领域的应用日益突出。间充质干细胞在多种疾病的治疗研究中已显示出良好的前景,并已成为治疗某些妇产科疾病的创新解决方案的新来源。本综述系统地介绍了利用间充质干细胞治疗妇产科相关疾病的最新研究。具体而言,本综述涵盖了有关间充质干细胞在卵巢早衰、多囊卵巢综合征、卵巢癌、输卵管相关疾病、宫腔粘连、子宫内膜异位症、剖宫产瘢痕缺损、绝经后骨质疏松症和盆底功能障碍等方面作用的最新研究成果。此外,还讨论了未来利用间充质干细胞治疗疾病的不足和挑战,旨在推动间充质干细胞在临床治疗中的应用。相信随着研究的深入,间充质干细胞将在妇产科相关疾病的治疗中发挥更重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mesenchymal stem cells: Guardians of women's health.

Mesenchymal stem cells (MSCs) have attracted more and more attention because of their multidirectional differentiation potential, immune regulatory abilities and self-renewal capacity. In recent years, their use has become prominent in the domains of regenerative medicine and tissue engineering. MSCs have shown promise in therapeutic studies for a variety of diseases and have become a new source of innovative solutions for the treatment of some obstetric and gynecological diseases. This review systematically presents the latest research on the use of MSCs in the treatment of obstetrics- and gynecology-related diseases. Specifically, this review encompasses the latest findings related to the role of MSCs in premature ovarian failure, polycystic ovary syndrome, ovarian cancer, fallopian tube-related diseases, uterine adhesions, endometriosis, cesarean scar defects, postmenopausal osteoporosis, and pelvic floor dysfunction. The shortcomings and challenges of the future use of MSCs in disease treatment are also discussed, with the intent to motivate improvements in MSC applications in clinical therapy. It is believed that with further research, MSCs will play a more important role in the treatment of obstetrics- and gynecology-related diseases.

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来源期刊
Regenerative Therapy
Regenerative Therapy Engineering-Biomedical Engineering
CiteScore
6.00
自引率
2.30%
发文量
106
审稿时长
49 days
期刊介绍: Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.
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