有丝分裂过程中内质网的动态重塑

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Journal of cell science Pub Date : 2024-11-15 Epub Date: 2024-11-25 DOI:10.1242/jcs.261444
Suzan Kors, Anne-Lore Schlaitz
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引用次数: 0

摘要

内质网(ER)是一个动态和连续的膜网络,在许多细胞过程中发挥作用。关于内质网结构和功能的重要性及其维持,人们已在间期细胞中进行了广泛研究,但最近的研究结果表明,内质网在有丝分裂过程中也起着至关重要的作用。在有丝分裂过程中,ER 在组成和形态上发生了显著的重塑,但作为一个连续的网络依然存在。ER与微管、肌动蛋白和中间丝相互作用,随着有丝分裂过程中所有细胞骨架系统的重组,ER的动态和分布也发生了变化。有丝分裂过程中,ER 是新陈代谢的枢纽,有几个例子说明了 ER 功能的改变。然而,我们对有丝分裂过程中活跃的ER代谢途径和功能还缺乏全面的了解。在这篇综述中,我们将讨论有丝分裂过程中ER在不同组织水平上的变化,以探讨有丝分裂过程中具有独特性质的ER可能如何支持细胞分裂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamic remodelling of the endoplasmic reticulum for mitosis.

The endoplasmic reticulum (ER) is a dynamic and continuous membrane network with roles in many cellular processes. The importance and maintenance of ER structure and function have been extensively studied in interphase cells, yet recent findings also indicate crucial roles of the ER in mitosis. During mitosis, the ER is remodelled significantly with respect to composition and morphology but persists as a continuous network. The ER interacts with microtubules, actin and intermediate filaments, and concomitant with the mitotic restructuring of all cytoskeletal systems, ER dynamics and distribution change. The ER is a metabolic hub and several examples of altered ER functions during mitosis have been described. However, we lack an overall understanding of the ER metabolic pathways and functions that are active during mitosis. In this Review, we will discuss mitotic changes to the ER at different organizational levels to explore how the mitotic ER, with its distinct properties, might support cell division.

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来源期刊
Journal of cell science
Journal of cell science 生物-细胞生物学
CiteScore
7.30
自引率
2.50%
发文量
393
审稿时长
1.4 months
期刊介绍: Journal of Cell Science publishes cutting-edge science, encompassing all aspects of cell biology.
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