Miao-Hsi Hsieh, Natalia Paramonova, Brigita Gradauskiene Sitkauskiene, Ilva Trapina, Ingrida Rumba-Rozenfelde, Sonomjamts Munkhbayarlakh, Samanta Plavina, Nikolajs Sjakste, Daina Bastyte, Laura Tamasauskiene, Ieva Stakaitiene, Rasa Ugenskiene, Pei-Chi Chen, Jiu-Yao Wang, Lawrence Shih-Hsin Wu
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Non-asthmatic individuals from Taiwan had higher concentrations, while asthma subjects in both Taiwanese and Lithuanian populations showed lower levels compared to their non-asthma counterparts (both p-value < 0.001). VDBP polymorphisms were associated with asthma in the Latvian population, with the rs7041 GG vs. GT+TT showing an odds ratio (OR) of 1.72 (95% confidence interval (CI): 1.10-2.69, p = 0.016) and the rs4588 CC vs. CA+AA showing an OR of 1.88 (95%CI: 1.24-2.84, p = 0.003). However, this association was not observed in other populations.</p><p><strong>Conclusions: </strong>Our cross-ethnic study underscores the intricate relationship between VDBP genetic variations, vitamin D levels, and asthma vulnerability. 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引用次数: 0
摘要
背景:哮喘与维生素 D 轴有关:哮喘与维生素 D 轴有关。VDBP 的基因变异,尤其是 rs7041 和 rs4588,会影响循环中的维生素 D 水平。然而,关于它们与哮喘之间联系的数据并不一致,而且种族差异仍不明确:我们探讨了 VDBP 的遗传变异如何影响不同种族人群的维生素 D 水平和哮喘易感性:在我们的跨种族研究中,我们分析了台湾、蒙古、立陶宛和拉脱维亚人群的维生素 D 水平和 VDBP 多态性(rs7041 和 rs4588)。我们的研究包括 363 名哮喘受试者和 481 名非哮喘对照者。我们对 rs7041 和 rs4588 进行了基因分型,并评估了血清中 25- 羟维生素 D [25(OH)D] 的浓度,研究了 VDBP 多态性、维生素 D 水平和哮喘之间的关联:结果:研究发现,不同种族群体的维生素 D 水平存在明显差异。来自台湾的非哮喘患者体内的维生素 D 含量较高,而台湾和立陶宛人群中的哮喘患者体内的维生素 D 含量则低于非哮喘患者(P 值均小于 0.001)。在拉脱维亚人群中,VDBP 多态性与哮喘有关,rs7041 GG 与 GT+TT 的比值比 (OR) 为 1.72(95% 置信区间 (CI):1.10-2.69,p = 0.016),rs4588 CC 与 CA+AA 的比值比 (OR) 为 1.88(95%CI:1.24-2.84,p = 0.003)。然而,在其他人群中并未观察到这种关联:我们的跨种族研究强调了 VDBP 基因变异、维生素 D 水平和哮喘易感性之间错综复杂的关系。VDBP 多态性与哮喘的关联似乎因人群而异,这强调了细致理解这些关联的重要性。
Genetic variations in Vitamin D Binding Protein (VDBP) impact vitamin D level and asthma susceptibility across the four ethnic populations.
Background: Asthma are associated with the vitamin D axis. Genetic variations of VDBP, notably rs7041 and rs4588, influence circulating vitamin D levels. However, data on their link to asthma are inconsistent, and ethnic differences remain unclear.
Objective: We explored how genetic variations in VDBP affect vitamin D levels and susceptibility to asthma across diverse ethnic populations.
Methods: In our cross-ethnic study, we analyzed vitamin D levels and VDBP polymorphisms (rs7041 and rs4588) in Taiwanese, Mongolian, Lithuanian, and Latvian populations. Our study included 363 asthmatic subjects and 481 non-asthma controls. We performed genotyping for rs7041 and rs4588 and assessed serum concentrations of 25-hydroxyvitamin D [25(OH)D], examining the associations between VDBP polymorphisms, vitamin D levels, and asthma.
Results: The study found significant differences in vitamin D levels among ethnic groups. Non-asthmatic individuals from Taiwan had higher concentrations, while asthma subjects in both Taiwanese and Lithuanian populations showed lower levels compared to their non-asthma counterparts (both p-value < 0.001). VDBP polymorphisms were associated with asthma in the Latvian population, with the rs7041 GG vs. GT+TT showing an odds ratio (OR) of 1.72 (95% confidence interval (CI): 1.10-2.69, p = 0.016) and the rs4588 CC vs. CA+AA showing an OR of 1.88 (95%CI: 1.24-2.84, p = 0.003). However, this association was not observed in other populations.
Conclusions: Our cross-ethnic study underscores the intricate relationship between VDBP genetic variations, vitamin D levels, and asthma vulnerability. The association of VDBP polymorphisms with asthma seems to differ among populations, emphasizing the importance of a nuanced comprehension of these connections.
期刊介绍:
The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747
APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume.
APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand.
The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.