Vinícius Tejada Nunes, Itamar Luís Gonçalves, Elizandra Gomes Schmitt, Gênifer Erminda Schreiner, Laura Smolski Dos Santos, Silvia Muller de Moura Sarmento, Camila Berny Pereira, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini, Cristiane Casagrande Denardin
{"title":"柚子提取物（Citrus maxima）可减少肥胖患者外周血中的氧化损伤。","authors":"Vinícius Tejada Nunes, Itamar Luís Gonçalves, Elizandra Gomes Schmitt, Gênifer Erminda Schreiner, Laura Smolski Dos Santos, Silvia Muller de Moura Sarmento, Camila Berny Pereira, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini, Cristiane Casagrande Denardin","doi":"10.1093/toxres/tfae192","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To verify the level of oxidation of biomolecules in the peripheral blood of obese patients before and after incubation with the pummelo pulp extract at 25 mg/mL.</p><p><strong>Methods: </strong>This investigation included 241 individuals, distributed across the following groups: control (n = 69; 30 men and 39 women); pre-obesity (n = 78; 29 men and 49 women); level I obesity (n = 62; 20 men and 42 women); and level II or III obesity (n = 32; 11 men and 21 women).</p><p><strong>Results: </strong>TBARS and MN levels were significantly altered by incubation with pummelo extract in both genders and in all the groups according to their obesity level. Another alteration in the antioxidant profile of the samples was a significant increase in vitamin C levels observed after incubation with pummelo extract in all experimental groups.</p><p><strong>Conclusions: </strong>The aqueous extract of pummelo pulp showed <i>in vitro</i> biological activity against the oxidation of biomolecules, suggesting that its bioactive compounds may bring health benefits of obese patients.</p>","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae192"},"PeriodicalIF":2.2000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582075/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pummelo fruit extract (<i>Citrus maxima</i>) reduces oxidative damage in peripheral blood of obese patients.\",\"authors\":\"Vinícius Tejada Nunes, Itamar Luís Gonçalves, Elizandra Gomes Schmitt, Gênifer Erminda Schreiner, Laura Smolski Dos Santos, Silvia Muller de Moura Sarmento, Camila Berny Pereira, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini, Cristiane Casagrande Denardin\",\"doi\":\"10.1093/toxres/tfae192\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To verify the level of oxidation of biomolecules in the peripheral blood of obese patients before and after incubation with the pummelo pulp extract at 25 mg/mL.</p><p><strong>Methods: </strong>This investigation included 241 individuals, distributed across the following groups: control (n = 69; 30 men and 39 women); pre-obesity (n = 78; 29 men and 49 women); level I obesity (n = 62; 20 men and 42 women); and level II or III obesity (n = 32; 11 men and 21 women).</p><p><strong>Results: </strong>TBARS and MN levels were significantly altered by incubation with pummelo extract in both genders and in all the groups according to their obesity level. Another alteration in the antioxidant profile of the samples was a significant increase in vitamin C levels observed after incubation with pummelo extract in all experimental groups.</p><p><strong>Conclusions: </strong>The aqueous extract of pummelo pulp showed <i>in vitro</i> biological activity against the oxidation of biomolecules, suggesting that its bioactive compounds may bring health benefits of obese patients.</p>\",\"PeriodicalId\":105,\"journal\":{\"name\":\"Toxicology Research\",\"volume\":\"13 6\",\"pages\":\"tfae192\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582075/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/toxres/tfae192\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/toxres/tfae192","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Pummelo fruit extract (Citrus maxima) reduces oxidative damage in peripheral blood of obese patients.
Objectives: To verify the level of oxidation of biomolecules in the peripheral blood of obese patients before and after incubation with the pummelo pulp extract at 25 mg/mL.
Methods: This investigation included 241 individuals, distributed across the following groups: control (n = 69; 30 men and 39 women); pre-obesity (n = 78; 29 men and 49 women); level I obesity (n = 62; 20 men and 42 women); and level II or III obesity (n = 32; 11 men and 21 women).
Results: TBARS and MN levels were significantly altered by incubation with pummelo extract in both genders and in all the groups according to their obesity level. Another alteration in the antioxidant profile of the samples was a significant increase in vitamin C levels observed after incubation with pummelo extract in all experimental groups.
Conclusions: The aqueous extract of pummelo pulp showed in vitro biological activity against the oxidation of biomolecules, suggesting that its bioactive compounds may bring health benefits of obese patients.
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