大马士革蔷薇提取物胶囊对更年期妇女性功能的影响：随机临床试验

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing Pub Date : 2024-11-16 DOI:10.1016/j.explore.2024.103082

Zohreh Gholinezhad , Fatemeh Zahra Karimi , Hassan Rakhshandeh , Seyed Reza Mazloum

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引用次数: 0

摘要

目的虽然性功能障碍在更年期妇女中的发病率很高，而且会给她们带来很多问题，但这一问题在很大程度上被忽视了。本研究旨在确定大马士革蔷薇提取物胶囊对更年期妇女性功能的影响。材料和方法本随机、三重盲法临床试验的对象是 82 名更年期妇女，她们被随机分为两组。干预组妇女每 12 小时服用一粒大马士革蔷薇提取物胶囊，连续服用 8 周；安慰剂组妇女服用无药效的类似胶囊。干预前后（4 周和 8 周）对女性性功能指数（FSFI）进行了评估。数据采用 SPSS 软件和独立 t 检验、曼-惠特尼 U 检验、卡方检验等统计检验方法进行分析，显著性水平为 0.05。结果使用大马士革蔷薇提取物胶囊能显著提高干预后 4 周（P = 0.016）和 8 周（P <0.001）的 FSFI 总分。干预组在 FSFI 方面的积极变化如下：干预 4 周和 8 周后的唤醒、润滑、满意度和性交疼痛。结论：本研究结果表明，大马士革蔷薇可以改善更年期妇女的性功能。结论

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Impact of Rosa damascena extract capsule on the sexual function of menopausal women: A randomized clinical trial

Objective

Although the prevalence of sexual dysfunction is high in menopausal women and it can cause many problems for them, it has been largely overlooked. The present study aimed to determine the effect of Rosa damascena extract capsules on the sexual function of menopausal women.

Materials and methods

This randomized, triple blinded clinical trial was conducted on 82 menopausal women who were randomly divided into two groups. In the intervention group, women took a capsule of Rosa damascena extract every 12 h for 8 weeks, while women in the placebo group took similar capsules without medicinal effects. The Female Sexual Function Index (FSFI) was evaluated before and after the intervention (4 and 8 weeks). The data were analyzed by SPSS software and statistical tests such as independent t-test, Mann‒Whitney U test, and Chi-square, with a significance level of 0.05.

Results

The use of Rosa damascena extract capsules significantly improved the total FSFI score four (P = 0.016) and eight weeks after the intervention (P < 0.001). The positive changes in FSFI domains in the intervention group were as follows: arousal, lubrication, satisfaction, and pain during intercourse four and eight weeks after the intervention. Additionally, desire and orgasm significantly increased eight weeks after the intervention (P < 0.05).

Conclusion

The results of this study indicate that Rosa damascena can improve sexual function in menopausal women. However, further studies are needed.

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来源期刊

Explore-The Journal of Science and Healing 医学-全科医学与补充医学

CiteScore

3.00

自引率

8.30%

发文量

179

审稿时长

25 days

期刊介绍： EXPLORE: The Journal of Science & Healing addresses the scientific principles behind, and applications of, evidence-based healing practices from a wide variety of sources, including conventional, alternative, and cross-cultural medicine. It is an interdisciplinary journal that explores the healing arts, consciousness, spirituality, eco-environmental issues, and basic science as all these fields relate to health.