耐碳青霉烯类鲍曼不动杆菌引起全球对新抗生素方案的警惕

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-11-12 DOI:10.1016/j.isci.2024.111367

Aswin Thacharodi , Avadh Vithlani , Saqib Hassan , Ali Alqahtani , Arivalagan Pugazhendhi

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引用次数: 0

摘要

耐碳青霉烯类鲍曼不动杆菌（CRAB）是引起院内感染的首要病原体，会增加发病率和死亡率。由于药代动力学的限制，CRAB 的治疗方案相对有限，例如严重的毒性。因此，我们必须更好地了解这种病原体，以开发新的治疗方法和控制策略。本综述旨在概述目前对鲍曼不动杆菌的获得性、适应性和固有卡巴培南耐药途径的了解，以及其对医疗保健系统（尤其是重症监护病房）的影响。本综述还深入探讨了目前全球是如何处理 CRAB 感染的，以及为什么需要新的治疗方案。此外，还进一步讨论了鲍曼不动杆菌的特殊性及其经常报道的毒力因子。总之，这篇综述的目的是强调目前有关 CRAB 的知识，因为它在医院内感染领域和整个公共卫生领域都引起了极大的担忧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Carbapenem-resistant Acinetobacter baumannii raises global alarm for new antibiotic regimens

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Carbapenem-resistant Acinetobacter baumannii raises global alarm for new antibiotic regimens

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a top-priority pathogen causing a nosocomial infection that increases morbidity and mortality. Treatment options for CRAB are relatively limited by pharmacokinetic restrictions, such as substantial toxicity. Therefore, we must better understand this pathogen to develop new treatments and control strategies. The review aims to provide an overview of the current understanding of acquired, adaptive, and intrinsic Carbapenem-resistant pathways in A. baumannii, as well as its consequences on healthcare systems, particularly critical care units. The review also provides insights into how CRAB infections are currently managed worldwide and why novel therapeutic regimens are needed. The peculiarity of A. baumannii and its often reported virulence factors have been discussed further. In conclusion, the purpose of this review is to emphasize the current knowledge on CRAB, as it causes major worry in the field of nosocomial infections as well as overall public health.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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