通过钯催化级联偶联反应合成 2,4,5-乙烯基三取代噁唑

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-11-21 DOI:10.1016/j.tetlet.2024.155373

Jun Ma , Huali Wang , Qingyu Meng , Haoyue Wang , Fangyi Li , Zheng Li

引用次数: 0

摘要

本文介绍了一步合成有价值的 2,4,5-乙烯基三取代噁唑的新方法。该反应以现成的 β,β-二溴化仲烯酰胺和末端烯为起始原料，通过无配体钯催化的级联分子内 CO 偶联/分子间 Heck 反应进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 2,4,5-vinylic-trisubstituted oxazoles via a Palladium-catalyzed cascade coupling reaction

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Synthesis of 2,4,5-vinylic-trisubstituted oxazoles via a Palladium-catalyzed cascade coupling reaction

A novel one-step synthesis of valuable 2,4,5-vinylic-trisubstituted oxazoles is described. This reaction, utilizing readily available β,β-dibrominated secondary enamides and terminal alkenes as starting materials, occurs via a ligand-free Palladium-catalyzed cascade intramolecular CO coupling/intermolecular Heck reaction.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.