钯催化的分子间 [5+2] 环加成反应：高区域选择性合成含烯的 2-苯并氧杂环庚烷

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-11-24 DOI:10.1002/ejoc.202401134

Bingyu Shen, Aimei Yang, Xihong Lu, Zhijun Xin, Xuehu Li

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引用次数: 0

摘要

开发了钯催化丙炔基碳酸酯与苄基烯基醚的分子间[5+2]环加成反应，用于合成含烯的 2-苯并氧杂环庚烷。该反应的进行途径包括脱羧性烯基钯形成、区域选择性分子间插入和分子内亲核攻击。通过这种方式，C-C 键和 C-O 键依次形成，从而在一锅反应过程中生成 2-苯并氧杂环庚烷骨架。

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Palladium-Catalyzed Intermolecular [5+2] Cycloaddition: Highly Regioselective Synthesis of Allene-Containing 2-Benzoxepines

Palladium-catalyzed intermolecular [5+2] cycloaddition of propargylic carbonates with benzyl allenyl ethers has been developed for the synthesis of allene-containing 2-benzoxepines. The reaction proceeds by a pathway involving decarboxylative allenylpalladium formation, regioselective intermolecular insertion, and intramolecular nucleophilic attack. In this way, the sequential formation of C−C and C−O bonds results in the generation of a 2-benzoxepine skeleton in a one-pot process.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.