揭示线粒体转移在癌症进展中的作用：卵巢癌透视。

IF 3.8 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2024-11-23 DOI:10.1186/s13048-024-01560-8

Caixia Wang, Chuan Xie

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引用次数: 0

摘要

线粒体是一种动态细胞器，与新陈代谢过程、重要生物通路的协调以及肿瘤发生和发展密不可分。最近的研究发现，线粒体可通过多种机制在细胞间转移，这与卵巢癌的发病机制和进展有关。本综述全面分析了卵巢癌及其肿瘤微环境背景下的细胞间线粒体转移。我们还提出了可用于调节线粒体转移治疗相关疾病的靶向途径和治疗策略。最后，我们探讨了这一领域的最新进展，并指出了几个尚未解决的问题。

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Unveiling the power of mitochondrial transfer in cancer progression: a perspective in ovarian cancer.

Mitochondria are dynamic organelles integral to metabolic processes, coordination of essential biological pathways, and oncogenesis and tumor progression. Recent studies have revealed that mitochondria can be transferred between cells via multiple mechanisms, implicating their involvement in the pathogenesis and progression of ovarian cancer. This review provides a comprehensive analysis of intercellular mitochondrial transfer within the context of ovarian cancer and its tumor microenvironment. We also propose targeted pathways and therapeutic strategies that could be utilized to modulate diseases associated with mitochondrial transfer therapy. Finally, we examine recent advancements in this field and identify several unresolved questions.

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.