志愿服务是否会降低退休和在职老年人的表观遗传年龄加速度？健康与退休研究的结果。

IF 4.9 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Social Science & Medicine Pub Date : 2024-11-13 DOI:10.1016/j.socscimed.2024.117501

Seoyoun Kim , Cal Halvorsen , Claire Potter , Jessica Faul

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引用次数: 0

摘要

研究目的本研究旨在探讨志愿服务频率与生物衰老（以表观遗传年龄加速度衡量）之间的关系。研究还探讨了这种关系在退休老年人和在职老年人之间是否存在差异。了解这种关系可为促进健康老龄化和减少与年龄相关的慢性健康问题的干预措施提供依据：数据来自健康与退休研究（HRS），包括治疗前协变量（2012年）、志愿者频率和工作状态（2014年）以及五项DNA甲基化测量（2016年）（N = 2,605）。研究人员估算了广义线性模型，以考察志愿服务与表观遗传年龄加速之间的关系，并按退休状况进行了分层。分析对相关协变量进行了调整，并利用能量平衡权重来考虑志愿服务的选择：结果：研究结果表明，志愿服务，尤其是每年 1-49 小时和每年 200 小时以上的志愿服务，与较少的表观遗传年龄加速有关，对 DNA 甲基化测量 PhenoAge、GrimAge 和 DunedinPACE 时钟有显著影响。在退休人员中，适度的志愿服务与表观遗传学年龄加速显著相关，这表明退休人员比在职人员受益更大：该研究发现，经常参加志愿服务可能会导致表观遗传学衰老减速，从而有可能提供一种公共卫生干预措施，提高老年人的健康水平和生活质量。还需要进一步的研究来证实这些发现，并了解志愿服务如何对退休人员和在职人员产生不同的影响。这些见解可以指导制定有针对性的战略，以促进健康老龄化和解决与年龄相关的健康差异。

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Does volunteering reduce epigenetic age acceleration among retired and working older adults? Results from the Health and Retirement Study

Objectives

The current study aims to explore the relationship between the frequency of volunteering and biological aging, as measured by epigenetic age acceleration. It also investigates whether this relationship differs between retired and working older adults. Understanding this connection could inform interventions promoting healthy aging and reducing age-related chronic health conditions.

Method

Data were derived from the Health and Retirement Study (HRS), including pre-treatment covariates (2012), volunteer frequency and work status (2014), and five DNA methylation measures (2016) (N = 2,605). Generalized linear models were estimated to examine the relationship between volunteering and epigenetic age acceleration, stratified by retirement status. The analyses adjusted for relevant covariates and utilized energy balancing weights to account for selection into volunteering.

Results

Findings show that volunteering, especially for 1–49 h per year and 200+ hours per year, was linked to less epigenetic age acceleration, with significant effects on DNA methylation measures PhenoAge, GrimAge, and DunedinPACE clocks. Among retired individuals, moderate volunteering was significantly associated with decelerated epigenetic age acceleration, indicating greater benefits for retirees compared to working individuals.

Conclusions

The study found that frequent volunteering may lead to decelerated epigenetic aging, potentially offering a public health intervention to enhance health and quality of life among older adults. Further research is needed to confirm these findings and to understand how volunteering might differentially impact retired and working individuals. Such insights could guide the development of targeted strategies to promote healthy aging and address age-related health disparities.

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来源期刊

Social Science & Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

9.10

自引率

5.60%

发文量

762

审稿时长

38 days

期刊介绍： Social Science & Medicine provides an international and interdisciplinary forum for the dissemination of social science research on health. We publish original research articles (both empirical and theoretical), reviews, position papers and commentaries on health issues, to inform current research, policy and practice in all areas of common interest to social scientists, health practitioners, and policy makers. The journal publishes material relevant to any aspect of health from a wide range of social science disciplines (anthropology, economics, epidemiology, geography, policy, psychology, and sociology), and material relevant to the social sciences from any of the professions concerned with physical and mental health, health care, clinical practice, and health policy and organization. We encourage material which is of general interest to an international readership.