用于骨组织工程的仿生矿化胶原支架：提高生物活性的精细制造策略

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2024-11-24 DOI:10.1002/smll.202406441

Bingfeng Wu, Xiaohong Li, Rui Wang, Liu Liu, Dingming Huang, Ling Ye, Zhenming Wang

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引用次数: 0

摘要

仿生矿化胶原（BMC）支架是一类创新的骨修复生物材料，其灵感来源于骨组织的天然生物矿化过程。由于具有良好的生物相容性和机械性能，BMC 支架在骨组织工程中备受关注。然而，大多数研究都忽视了生物活性的重要性，导致胶原支架的成骨潜力不理想。本综述讨论了骨组织中矿化细胞外基质（ECM）的组成，为仿生胶原矿化提供指导。随后，根据 BMC 支架的详细制作过程，总结了可调节制作过程和生物活性的物质。此外，还提出了一种潜在的策略，以开发具有优异机械性能和生物活性的 BMC 支架，用于骨组织工程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

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Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement

Biomimetic mineralized collagen (BMC) scaffolds represent an innovative class of bone‐repair biomaterials inspired by the natural biomineralization process in bone tissue. Owing to their favorable biocompatibility and mechanical properties, BMC scaffolds have garnered significant attention in bone tissue engineering. However, most studies have overlooked the importance of bioactivity, resulting in collagen scaffolds with suboptimal osteogenic potential. In this review, the composition of the mineralized extracellular matrix (ECM) in bone tissue is discussed to provide guidance for biomimetic collagen mineralization. Subsequently, according to the detailed fabrication procedure of BMC scaffolds, the substances that can regulate both the fabrication process and biological activities is summarized. Furthermore, a potential strategy for developing BMC scaffolds with superior mechanical properties and biological activities for bone tissue engineering is proposed.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.