低分次放射治疗是否用于治疗软组织肉瘤？利用NETSARC网络对实践进行评估。

IF 1.5 4区医学 Q4 ONCOLOGY

Cancer Radiotherapie Pub Date : 2024-12-01 DOI:10.1016/j.canrad.2024.05.007

Emma Agnoux , Anaïs Stefani , Nassim Sahki , Émilie Meknaci , Maria Jolnerovski

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引用次数: 0

摘要

目的：治疗四肢软组织肉瘤的方法是进行大范围手术切除，同时进行正常分次放疗。过去 3 年中，出现了几项关于围手术期低分量放疗的 II 期试验。我们的目的是回顾法国和卢森堡目前将超分割放疗作为治疗四肢软组织肉瘤的方法：我们向隶属于NETSARC网络的法国和卢森堡大公国28个中心的肉瘤放射肿瘤专家发送了一份电子自适应调查问卷。问卷于2021年12月和2022年1月通过NETSARC邮件列表发布。问卷包括四至九个问题，答案为封闭式多选或开放式（长或短）。其中一些问题评估了对四肢软组织肉瘤术前或术后低分次放射治疗建议的同意程度：结果：在接受调查的 28 位放射肿瘤学家中，来自 9 个中心的 11 位（39.2%）做出了回答。其中，55%的放射肿瘤科医生采用了低分次放射治疗，主要用于年老体弱的患者。未使用低分次放射治疗的主要原因是缺乏科学证据和治疗习惯：结论：针对四肢软组织肉瘤的低剂量放射治疗仍有待高功率研究的检验，但未来可由肉瘤转诊中心的多学科委员会为经过严格筛选的患者提供低剂量放射治疗。

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Is hypofractionated radiotherapy used to treat soft tissue sarcomas? Assessment of practices using the NETSARC network

Purpose

Extremity soft-tissue sarcomas are treated by wide surgical resection with normofractionated radiotherapy. Over the past 3 years, several phase II trials emerged on perioperative hypofractionated radiotherapy. We aimed to review the current practice in France and Luxembourg of hypofractionated radiotherapy as curative treatment for extremity soft-tissue sarcomas.

Materials and methods

We sent an electronic adaptive survey to sarcoma radiation oncologists at 28 centres in France and the Grand Duchy of Luxembourg belonging to the NETSARC network. The questionnaire was distributed via the NETSARC mailing list in December 2021 and January 2022. It consisted of four to nine questions with closed multiple choice, or open-ended (short or long) answers. Some questions assessed agreement with proposals for pre- or postoperative hypofractionated radiotherapy for extremity soft-tissue sarcomas.

Results

Of the 28 radiation oncologists surveyed, 11 (39.2 %) from nine centres responded. Of these, 55 % used hypofractionated radiotherapy, mainly for elderly and frail patients. The main reason why hypofractionated radiotherapy was not used was the lack of scientific evidence and therapeutic habits.

Conclusion

Hypofractionated radiotherapy for extremity soft-tissue sarcomas remains to be investigated in high-powered studies but could be offered in the future for well-selected patients by a multidisciplinary board in a sarcoma referral centre.

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来源期刊

Cancer Radiotherapie 医学-核医学

CiteScore

2.20

自引率

23.10%

发文量

129

审稿时长

63 days

期刊介绍： Cancer/radiothérapie se veut d''abord et avant tout un organe francophone de publication des travaux de recherche en radiothérapie. La revue a pour objectif de diffuser les informations majeures sur les travaux de recherche en cancérologie et tout ce qui touche de près ou de loin au traitement du cancer par les radiations : technologie, radiophysique, radiobiologie et radiothérapie clinique.