与含乙醛酸盐的头发拉直产品有关的草酸盐肾病：需要警惕。

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-11-20 DOI:10.1016/j.kint.2024.09.015

Naim M. Maalouf , Jonathan M. Whittamore

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引用次数: 0

摘要

最近有报道称，健康人在接触拉直头发产品后会出现急性肾损伤。在本期杂志中，Robert 等人通过一个复制人类病理的小鼠模型，帮助阐明了其基本机制。皮肤吸收拉直头发产品中的乙醛酸并随后将其转化为草酸盐，被认为是草酸盐肾病发病的关键步骤。这一新描述的 "皮肤-肾脏 "轴线扩展了我们对草酸盐代谢的了解，要求进行更多的研究以探索皮肤接触乙醛酸后急性肾损伤的易感性，并需要对这些产品的使用保持警惕。

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Oxalate nephropathy associated with glyoxylate-containing hair-straightening products: a call for caution

Recent reports have described acute kidney injury in otherwise healthy individuals after exposure to hair-straightening products. In this issue, Robert et al. help elucidate the underlying mechanisms in a murine model that replicates the human pathology. Cutaneous absorption of glyoxylic acid from hair-straightening products and its subsequent conversion to oxalate are identified as crucial steps in the development of oxalate nephropathy. This newly described “skin-kidney” axis expands our understanding of oxalate metabolism, calls for additional studies to explore susceptibility to acute kidney injury following cutaneous glyoxylate exposure, and warrants vigilance around the use of these products.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.