在以色列，"10 月 7 日 "事件与试管婴儿结果之间有关联吗？

IF 3.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Reproductive biomedicine online Pub Date : 2024-08-23 DOI:10.1016/j.rbmo.2024.104429

Einav Kadour-Peero , Chen Shkolnik , Janan Jadon , Rabea Bahous , Yael Gonen , Michal Silberman , Ilan Calderon , Hadar Avraham , Samer Khoury

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引用次数: 0

摘要

研究问题：在以色列，2023 年 "10 月 7 日 "事件与试管婴儿结果之间是否存在关联？设计：在这项回顾性队列研究中，研究组是在 "10 月 7 日 "之后 4 周内接受治疗的女性，与在 2021 年 1 月 1 日至 2023 年 10 月 6 日期间接受治疗的匹配对照组进行比较。每个研究组的参与者都与三个独立的对照组受试者进行了配对，这些受试者在取卵时的女性年龄相同，体重指数（BMI）、试管婴儿周期数和卵巢储备参数也相匹配：研究包括 580 名患者。在 2023 年 10 月 7 日之后进行了取卵或冷冻胚胎移植的 145 名女性与 10 月 7 日之前接受治疗的 435 名女性进行了比较。研究组的平均年龄为 35.6 ± 5.9 岁，平均体重指数为 25.01 ± 5.60 kg/m2。两组每次胚胎移植的妊娠率相似（新鲜周期为 22.4% 对 30.5%，P = 0.28；冷冻胚胎移植为 16.9% 对 27.1%，P = 0.12）。在进行卵母细胞提取的妇女中，卵巢刺激方案（P = 0.95）、提取的卵母细胞数（P = 0.16）或受精卵母细胞数（P = 0.34）均无差异。各组之间的优质胚胎率没有差异（P = 0.053）。在接受冷冻胚胎移植的妇女中，研究期间自然周期的患者较多（52.5% 对 24%，P < 0.001），胚胎移植前最大子宫内膜厚度没有差异（P = 0.33）：结论："10 月 7 日 "事件与试管婴儿结果之间似乎没有关联。

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Is there an association between the ‘October 7th’ events and IVF outcomes in Israel?

Research question

Is there an association between the ‘October 7th’ 2023 events and IVF outcomes in Israel?

Design

in this retrospective cohort study the study group was women treated during the 4 weeks after ‘October 7th’, compared with a matched control group treated between 1 January 2021 and 6 October 2023. Each study group participant was matched with three separate control subjects of the same female age at oocyte retrieval, with a matching body mass index (BMI), IVF cycle number and ovarian reserve parameters.

Results

The study included 580 patients. The 145 women who underwent oocyte retrieval or frozen embryo transfer after 7 October 2023 were compared with 435 women treated before 7 October. The mean age of the study group was 35.6 ± 5.9 years, and the mean BMI 25.01 ± 5.60 kg/m². Pregnancy rates per embryo transfer were similar between the groups (22.4% versus 30.5%, P = 0.28 in fresh cycles; 16.9% versus 27.1%, P = 0.12 in frozen embryo transfers). Among women who underwent oocyte retrieval there were no differences in the ovarian stimulation protocols (P = 0.95), number of oocytes retrieved (P = 0.16) or number of fertilized oocytes (P = 0.34). There was no difference in the rate of good-quality embryos between groups (P = 0.053). Among women who underwent frozen embryo transfers, during the study period more patients had natural cycles (52.5% versus 24%, P < 0.001), and there was no difference in maximal endometrial thickness before embryo transfer (P = 0.33).

Conclusions

It appears that there is no association between the ‘October 7’ events and IVF outcomes.

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来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.