西班牙地中海沿岸多发性硬化症患者磁共振成像中钆增强病变的观察研究：季节变化及与气候因素的关系。

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2024-11-10 DOI:10.1016/j.msard.2024.106164

Celia Romero Del Rincón , Berta Claramonte-Clausell , Clara Aguirre , Marta Domiguez-Gallego , Virginia Meca-Lallana , Antonio Belenguer Benavides

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引用次数: 0

摘要

导言：环境因素似乎在多发性硬化症（MS）的发展和病程中起着重要作用。疾病活动的季节性变化已得到描述，并推测它可能因地理区域而异。本研究的目的是分析磁共振成像（MRI）观察到的疾病活动的每月分布情况，并寻找复发缓解型多发性硬化症患者的疾病活动与气候之间可能存在的关系：回顾性观察研究，在西班牙地中海沿岸一家医院的人群中开展。共对 51 名患者的 238 次磁共振成像扫描进行了评估。气候数据来自西班牙国家气象局 2012 年至 2016 年的数据。造影剂增强病变即为活动性：结果发现，钆增强病变在不同月份的分布并不均匀（p = 0.008）。目测显示，7 月和 8 月的活动度较高。在天气方面，热带夜晚（定义为最低气温高于20 °C的日子）与磁共振成像活动风险增加有关（OR = 1.06，p = 0.001）：这些研究结果表明，钆增强病灶的月度分布不均匀，较温暖的夜晚与核磁共振成像活动增加之间存在关联，这表明环境因素对神经影像学中多发性硬化活动具有潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Observational study of gadolinium-enhancing lesions in MRI in patients with multiple sclerosis from the Spanish Mediterranean coast: Seasonal variability and relationship with climatic factors

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Observational study of gadolinium-enhancing lesions in MRI in patients with multiple sclerosis from the Spanish Mediterranean coast: Seasonal variability and relationship with climatic factors

Introduction

Environmental factors appear to play an important role in the development and course of Multiple Sclerosis (MS). Seasonal variability in disease activity has been described and it is postulated that it may vary according to geographical area. The aim of this study is to analyse the monthly distribution of activity observed on Magnetic Resonance Imaging (MRI) and to look for a possible relationship with climate in patients with relapsing remitting MS.

Material and methods

Retrospective observational study, carried out in the population of one hospital on the Spanish Mediterranean coast. A total of 238 MRI scans of 51 patients were evaluated. Climatological data were obtained from the Spanish State Meteorological Agency from 2012 to 2016. Activity was defined as contrast-enhancing lesions.

Results

The distribution of gadolinium-enhancing lesions was found to be non-uniform across months (p = 0.008). Visual inspection suggests higher activity in July and August. Regarding weather, tropical nights (defined as days with a minimum temperature above 20 °C) were associated with increased risk of MRI activity (OR = 1.06, p = 0.001).

Conclusion

These findings suggest a non-uniform monthly distribution of gadolinium-enhancing lesions and an association between warmer nights and increased MRI activity, pointing to a potential impact of environmental factors on multiple sclerosis activity in neuroimaging.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.