威灵仙茎中的二萜和木脂素及其抗炎活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-11-19 DOI:10.1016/j.fitote.2024.106306

Yulu Tian, Yazi Wei, Haowen Luo, Xinyi Chen, Jie Ma, Yingda Zang, Tiantai Zhang, Dongming Zhang, Chuangjun Li

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引用次数: 0

摘要

从 Tripterygium wilfordii（T. wilfordii）的茎中获得了两种未被描述的二萜类化合物（1-2）和三种木脂素（3a/3b, 4a），以及 16 种已知化合物（4b, 5-9, 10a/10b-14a/14b）。通过详细的光谱分析阐明了这些新化合物的结构，并通过 ECD 计算确定了它们的绝对构型。一些化合物在体外对 LPS 刺激的 RAW 264.7 巨噬细胞产生的 IL-6 有中等程度的抑制作用。化合物 5 在体外表现出明显的抗炎活性（IC50，0.77 μM），并抑制巨噬细胞向促炎表型极化。

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Diterpenoids and lignans from the stems of Tripterygium wilfordii and their anti-inflammatory activities.

Two undescribed diterpenoids (1-2) and three lignans (3a/3b, 4a), together with sixteen known compounds (4b, 5-9, 10a/10b-14a/14b) were obtained from the stems of Tripterygium wilfordii (T. wilfordii). The structures of these new compounds were elucidated by detailed spectroscopic analyses, and their absolute configurations were estabished by ECD calculations. Some compounds exhibited moderate inhibitory activities against IL-6 production in LPS-stimulated RAW 264.7 macrophages in vitro. Compound 5 showed significant anti-inflammatory activity in vitro (IC₅₀, 0.77 μM) and inhibited macrophage polarization towards a pro-inflammatory phenotype.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.