质子-中子联合辐照体外肿瘤细胞的有效性研究

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI:10.1007/s10517-024-06285-8

S N Koryakin, M V Troshina, E V Koryakina, V I Potetnya, A A Pichkunova, V O Saburov, E I Kazakov, A A Lychagin, S A Ivanov, A D Kaprin, V I Zverev, A Yu Presnyakov

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引用次数: 0

摘要

质子-中子联合疗法是中子放射治疗的最佳机会，因为质子辐照具有高度保形性，而中子具有较高的相对生物有效性。该研究比较了将中国仓鼠纤维肉瘤细胞 B14-150 依次体外照射 14.5 MeV 中子和质子扫描束的 4 种方案。随着中子部分在总剂量中所占比例从30%增加到40%，以及中子剂量作为质子-中子两部分照射的第一部分，治疗效率也随之提高。

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The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro.

Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons. Treatment efficiency increased with increasing the contribution of the neutron component to the total dose from 30 to 40% and the delivery of the neutron dose as the first fraction in the two-fraction proton-neutron exposure.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.