异丙肾上腺素诱发 24 个月大鼠慢性心力衰竭的模型试验

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI:10.1007/s10517-024-06277-8

T Yu Rebrova, V A Korepanov, I V Stepanov, S A Afanasiev

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引用次数: 0

摘要

在体重为 550-600 克的 24 个月大雄性 Wistar 大鼠身上，以 10 毫克/千克的剂量皮下注射 4 次盐酸异丙肾上腺素（ISO），间隔 3 天，诱发慢性心力衰竭（CHF）。对照组注射生理盐水。大鼠在最后一次注射 ISO 或生理盐水 60 天后被安乐死。患有慢性心力衰竭的大鼠死亡率为 30%。组织学研究显示，心肌、肾脏和肺部出现了典型的 CHF 形态学变化。所介绍的 ISO 给药方案可用于为 24 个月大的大鼠建立 CHF 模型。

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Modeling of Isoproterenol-Induced Chronic Heart Failure in 24-Month-Old Rats.

The development of chronic heart failure (CHF) was induced in 24-month-old male Wistar rats weighing 550-600 g by 4 subcutaneous injections of isoproterenol hydrochloride (ISO) at a dose of 10 mg/kg with 3-day intervals. The control group received injections of saline. The rats were euthanized 60 days after the last ISO/saline injection. The mortality rate in the group of rats with CHF was 30%. Histological studies showed morphological changes in the myocardium, kidneys, and lungs typical of CHF. The presented scheme of ISO administration can be used for modeling CHF in 24-month-old rats.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.