探讨维生素在预防神经退行性疾病中的作用:临床前和临床研究结果的全面回顾。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Liza Changkakoti, Rajan Rajabalaya, Sheba R David, Ashok Kumar Balaraman, Hemalatha Sivasubramanian, Ashis K Mukherjee, Asis Bala
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引用次数: 0

摘要

神经退行性疾病(NDDs)是一种多方面、异质性的复杂疾病。遗憾的是,目前还没有找到治愈这些疾病的方法,但有一些方法可以降低患上这些疾病的风险。研究表明,特定的维生素能调节大脑分子和信号通路,这可能有助于预防退化。本综述重点研究了维生素在预防五种重要的神经退行性疾病中的作用,包括帕金森病(PD)、阿尔茨海默病(AD)、亨廷顿氏病(HD)、多发性硬化症(MS)和肌萎缩侧索硬化症(ALS)。本综述还重点介绍了有关维生素对这类疾病潜在影响的有希望和有争议的研究结果。一些发达国家规定了每日膳食维生素摄入量的标准,以满足营养需求、改善健康状况并预防 NDD 等慢性疾病。然而,要更全面地了解维生素的治疗作用,还需要进行更多的研究,包括探索不同药物剂量范例的研究、多样化的人源化动物模型以及在不同地区进行的临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploration of the Role of Vitamins in Preventing Neurodegenerative Diseases: Comprehensive Review on Preclinical and Clinical Findings.

Neurodegenerative diseases (NDDs) are a multifaceted and heterogeneous group of complex diseases. Unfortunately, a cure for these conditions has yet to be found, but there are ways to reduce the risk of developing them. Studies have shown that specific vitamins regulate the brain molecules and signaling pathways, which may help prevent degeneration. This review focuses on examining the role of vitamins in preventing five significant types of neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). This review also highlights promising and controversial findings about the potential impact of vitamins on this group of diseases. Several developed countries standardize daily dietary vitamin intake to meet nutrient requirements, improve health, and prevent chronic diseases like NDDs. However, more research is necessary to gain a more comprehensive understanding of their therapeutic benefits, including studies exploring different drug-dose paradigms, diverse humanized animal models, and clinical trials conducted in various locations.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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