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引用次数: 0
摘要
摘要：一名患有急性髓性白血病（AML）并伴有单核细胞分化的20岁女性患者，病情缓解后，最近出现舌头上疼痛性凹陷性肿胀，并伴有发热。虽然她的外周血象正常，但骨髓活检提示急性髓细胞白血病复发。舌病变活检显示，固有膜和粘膜下层弥漫性浸润有爆破细胞，髓过氧化物酶和 CD11c 阳性，提示为口腔髓系肉瘤（MS）。这是一种不常见的 MS 发病部位，也是急性髓细胞性白血病复发的标志。该病例凸显了 MS 的多变表现。即使在没有外周血证据的情况下，也应警惕骨髓中血液恶性肿瘤的复发。
Oral Myeloid Sarcoma as a Marker of Relapse in Acute Myeloid Leukemia.
Abstract: A 20-year-old woman with acute myeloid leukemia (AML) with monocytic differentiation in remission presented with a recent onset painful indurated swelling on the tongue with fever. Although her peripheral blood picture was normal, the bone marrow biopsy was suggestive of a relapse of AML. A biopsy from the tongue lesion showed diffuse infiltration of lamina propria and submucosa by blast cells, positive for myeloperoxidase and CD11c and suggestive of oral myeloid sarcoma (MS). This presents an uncommon site of occurrence of MS and was a marker of relapse of AML. This case highlights the variable presentation of MS. It should prompt investigation for relapse of hematological malignancy in the bone marrow even in the absence of evidence from peripheral blood.
期刊介绍：
The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports.
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