从花粉草中发现两种新的长链脂肪酸酯黄酮醇苷及其对 HBMEC 的保护作用

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-11-21 DOI:10.1080/10286020.2024.2428238

Min-Jie Liu, Dong-Quan Gu, Ren-Zhong Wang, Kai-Di Wang, Si-Yu Wu, Shuang Han, De-Ling Wu, Feng-Qing Xu, Wu-Xi Zhou

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引用次数: 0

摘要

ABATRACT 从花粉刺五加（PTC）中分离出两种新化合物，即异鼠李素-3-O-新橙皮甙-6''-亚油酸酯（1）和异鼠李素-3-O-新橙皮甙-6''-棕榈酸酯（2），以及 17 种已知化合物。根据一维（1D）、二维（2D）核磁共振（NMR）和高分辨率电喷雾离子化质谱（HRESIMS）光谱数据分析，阐明了它们的结构。这两种新化合物（1 和 2）在氧-葡萄糖剥夺/复氧（OGD/R）诱导的人脑微血管内皮细胞（HBMECs）中表现出剂量依赖性的保护作用，并促进了管的生成。

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Discovery of two new long chain fatty acid esters of flavonol glycoside from Pollen Typhae Carbonisatus and their protective effects on HBMECs.

ABATRACTTwo new compounds, namely, isorhamnenin-3-O-neohesperidin-6''-linoleic acid ester (1) and isorhamnenin-3-O-neohesperidin-6''-palmitate (2), along with 17 known compounds, were isolated from Pollen Typhae Carbonisatus (PTC). Their structures were elucidated on the basis of one-dimensional (1D)-, two-dimensional (2D)-nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HRESIMS) spectroscopic data analyses. The two new compounds (1 and 2) exhibited a protective effect in a dose-dependent manner and promoted tube generation in the oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human brain microvascular endothelial cells (HBMECs).

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.