成功进行异基因造血干细胞移植治疗结节性 Epstein-Barr 病毒阳性 T/NK 细胞淋巴瘤。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2024-11-21 DOI:10.2169/internalmedicine.4672-24

Satoshi Ichikawa, Hiroaki Abe, Naoya Morota, Akihisa Kawajiri, Ryo Nakagawa, Kyoko Inokura, Shunsuke Hatta, Yuna Katsuoka, Koichi Onodera, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

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引用次数: 0

摘要

结节性爱泼斯坦-巴氏病毒阳性T/NK细胞淋巴瘤（EB-nTNKL）是一种极其罕见的疾病，其特点是临床过程凶险，预后不良，治疗策略尚未确立。我们在此报告了一名患有EB-nTNKL的年轻人。虽然包括L-天冬酰胺酶在内的初始化疗未能产生良好反应，但随后的髓鞘脱落异基因造血干细胞移植（alloHSCT）使病情得到了良好控制，并获得了长期无病生存。无论初始化疗是否有效，当时使用可用的供体来源及时进行异体造血干细胞移植对于挽救这种致命疾病的患者至关重要。

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Successful Allogeneic Hematopoietic Stem Cell Transplantation for Nodal Epstein-Barr Virus-positive T/NK-cell Lymphoma.

Nodal Epstein-Barr virus-positive T/NK-cell lymphoma (EB-nTNKL) is an extremely rare disease characterized by an aggressive clinical course and poor prognosis, for which treatment strategies have not yet been established. We herein report a young man with EB-nTNKL. Although initial chemotherapies, including L-asparaginase, failed to produce a good response, subsequent myeloablative allogeneic hematopoietic stem cell transplantation (alloHSCT) resulted in favorable disease control and a long-term disease-free survival. The prompt performance of alloHSCT using an available donor source at that time, regardless of whether or not the initial chemotherapy was effective, could be critical to saving patients with this otherwise fatal disease.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.