REM-NREM 睡眠周期的热力学模型

IF 5.3 1区数学 Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS

Chaos Solitons & Fractals Pub Date : 2024-11-20 DOI:10.1016/j.chaos.2024.115732

Haeun Sun, Yurii Ishbulatov, Anatoly Karavaev, Denis Zakharov, Alexey Zaikin

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引用次数: 0

摘要

尽管许多模型都能解释快速眼动（REM）和非快速眼动（NREM）这两种不同睡眠状态之间的自发交替，但关于小动物睡眠阶段转换期间温度的持续变化，已经积累了新的经验证据。神经兴奋性和低频（≤4 Hz）神经元活动的温度依赖性也得到了理论和实验研究。基于这些现象，我们构建了一个超昼夜睡眠节律的随机热力学模型。该模型通过模拟验证，显示出与大鼠实验数据一致的统计特性。该模型将为快速眼动周期背后的机制提供新的见解，并可应用于治疗睡眠障碍的新疗法。

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A thermodynamic model of the REM–NREM sleep cycle

Although many models explain the spontaneous alternation between two distinct sleep states, Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM), new empirical evidence has accumulated regarding consistent temperature changes during sleep stage transitions in small animals. The temperature dependence of neuro-excitability and low-frequency (≤4 Hz) neuronal activity has also been investigated theoretically and experimentally. Based on these phenomena, we constructed a stochastic thermodynamic model of the ultradian sleep rhythm. The model was validated through simulation, demonstrating statistical properties that align with experimental data from rats. This model would provide new insights into the mechanisms behind the REM cycle and can be applied in new therapies for sleep disorders.

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来源期刊

Chaos Solitons & Fractals 物理-数学跨学科应用

CiteScore

13.20

自引率

10.30%

发文量

1087

审稿时长

9 months

期刊介绍： Chaos, Solitons & Fractals strives to establish itself as a premier journal in the interdisciplinary realm of Nonlinear Science, Non-equilibrium, and Complex Phenomena. It welcomes submissions covering a broad spectrum of topics within this field, including dynamics, non-equilibrium processes in physics, chemistry, and geophysics, complex matter and networks, mathematical models, computational biology, applications to quantum and mesoscopic phenomena, fluctuations and random processes, self-organization, and social phenomena.