利用细胞周期依赖性去磷酸化实现有丝分裂特异性蛋白质招募

IF 81.3 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2024-11-20 DOI:10.1038/s41580-024-00808-x

Xiaofu Cao

引用次数: 0

摘要

在这篇 "贸易工具"（Tools of the Trade）文章中，Cao（Baskin 实验室）讨论了 MARS 的开发过程，MARS 利用细胞周期对 PLEKHA5 磷酸化的自然调控，实现了有丝分裂特异性地将酶招募到质膜上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment

In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma membrane, exploiting the cell cycle’s natural regulation of PLEKHA5 phosphorylation.

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.