{"title":"评估从高海拔地区返回中等海拔地区的大鼠的肺动脉压力、血液指数和心肌微循环。","authors":"Chunlong Yan, Jinfeng Ma, Dengfeng Tian, Tingjun Yan, Chenhong Zhang, Fengjuan Zhang, Yuchun Zhao, Shihan Fu, Qiang Zhang, Mengxue Xia, Yue Li, Yanqiu Sun","doi":"10.1186/s41747-024-00514-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To investigate changes in pulmonary artery pressure (PAP), blood indices, and myocardial microcirculation in rats returning from high altitude (HA) to moderate altitude (MA).</p><p><strong>Methods: </strong>Forty 4-week-old male Sprague-Dawley rats were randomly divided into four groups with ten rats in each group. One group was transported to the MA area (MA-group), and the other three groups were transported to HA (HA-group-A, HA-group-B, and HA-group-C). After 28 weeks of age, the rats from the HA area were transported to the MA area for 0 days, 10 days, and 20 days, respectively. PAP, routine blood tests, and computed tomography myocardial perfusion indices were measured.</p><p><strong>Results: </strong>Compared with the MA-group, the body weight of HA-groups decreased (p < 0.05), and PAP in HA-group-A and HA-group-B increased (p < 0.05). In the HA groups, PAP initially increased and then decreased. Compared with the MA-group, red blood cells (RBC), hemoglobin (HGB), and hematocrit (HCT) of rats in HA-group-A increased (p < 0.05). Compared with the HA-group-A, RBC, HGB, and HCT of HA-group-B gradually decreased (p < 0.05) while MCV decreased (p < 0.05), and PLT of HA-group-C increased (p < 0.05). Compared with the MA group, blood flow (BF) and blood volume (BV) of the HA-group-A decreased (p < 0.05). Compared with the HA-group-A, TTP increased first and then decreased (p < 0.05), and BF and BV increased gradually (p < 0.05). Pathological results showed that myocardial fiber arrangement was disordered, and cell space widened in the HA group.</p><p><strong>Conclusion: </strong>PAP, blood parameters, and myocardial microcirculation in rats returning from high to MA exhibited significant changes.</p><p><strong>Relevance statement: </strong>This study provides an experimental basis for understanding the physiological and pathological mechanisms during the process of deacclimatization to HA and offers new insights for the prevention and treatment of deacclimatization to HA syndrome.</p><p><strong>Key points: </strong>Forty rats were raised in a real plateau environment. Myocardial microcirculation was detected by CT myocardial perfusion imaging. The PAP of the unacclimated rats increased first and then decreased. The myocardial microcirculation of the deacclimated rats showed hyperperfusion changes.</p>","PeriodicalId":36926,"journal":{"name":"European Radiology Experimental","volume":"8 1","pages":"131"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579275/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of pulmonary artery pressure, blood indices, and myocardial microcirculation in rats returning from high altitude to moderate altitude.\",\"authors\":\"Chunlong Yan, Jinfeng Ma, Dengfeng Tian, Tingjun Yan, Chenhong Zhang, Fengjuan Zhang, Yuchun Zhao, Shihan Fu, Qiang Zhang, Mengxue Xia, Yue Li, Yanqiu Sun\",\"doi\":\"10.1186/s41747-024-00514-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>To investigate changes in pulmonary artery pressure (PAP), blood indices, and myocardial microcirculation in rats returning from high altitude (HA) to moderate altitude (MA).</p><p><strong>Methods: </strong>Forty 4-week-old male Sprague-Dawley rats were randomly divided into four groups with ten rats in each group. One group was transported to the MA area (MA-group), and the other three groups were transported to HA (HA-group-A, HA-group-B, and HA-group-C). After 28 weeks of age, the rats from the HA area were transported to the MA area for 0 days, 10 days, and 20 days, respectively. PAP, routine blood tests, and computed tomography myocardial perfusion indices were measured.</p><p><strong>Results: </strong>Compared with the MA-group, the body weight of HA-groups decreased (p < 0.05), and PAP in HA-group-A and HA-group-B increased (p < 0.05). In the HA groups, PAP initially increased and then decreased. Compared with the MA-group, red blood cells (RBC), hemoglobin (HGB), and hematocrit (HCT) of rats in HA-group-A increased (p < 0.05). Compared with the HA-group-A, RBC, HGB, and HCT of HA-group-B gradually decreased (p < 0.05) while MCV decreased (p < 0.05), and PLT of HA-group-C increased (p < 0.05). Compared with the MA group, blood flow (BF) and blood volume (BV) of the HA-group-A decreased (p < 0.05). Compared with the HA-group-A, TTP increased first and then decreased (p < 0.05), and BF and BV increased gradually (p < 0.05). Pathological results showed that myocardial fiber arrangement was disordered, and cell space widened in the HA group.</p><p><strong>Conclusion: </strong>PAP, blood parameters, and myocardial microcirculation in rats returning from high to MA exhibited significant changes.</p><p><strong>Relevance statement: </strong>This study provides an experimental basis for understanding the physiological and pathological mechanisms during the process of deacclimatization to HA and offers new insights for the prevention and treatment of deacclimatization to HA syndrome.</p><p><strong>Key points: </strong>Forty rats were raised in a real plateau environment. Myocardial microcirculation was detected by CT myocardial perfusion imaging. The PAP of the unacclimated rats increased first and then decreased. The myocardial microcirculation of the deacclimated rats showed hyperperfusion changes.</p>\",\"PeriodicalId\":36926,\"journal\":{\"name\":\"European Radiology Experimental\",\"volume\":\"8 1\",\"pages\":\"131\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579275/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Radiology Experimental\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41747-024-00514-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Radiology Experimental","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41747-024-00514-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
背景：研究从高海拔地区（HA）返回中等海拔地区（MA）的大鼠肺动脉压力（PAP）、血液指数和心肌微循环的变化：研究从高海拔地区（HA）返回中等海拔地区（MA）的大鼠肺动脉压力（PAP）、血液指数和心肌微循环的变化：将 40 只 4 周大的雄性 Sprague-Dawley 大鼠随机分为 4 组，每组 10 只。一组被送往 MA 地区（MA 组），另外三组被送往 HA 地区（HA-A 组、HA-B 组和 HA-C 组）。28 周龄后，HA 区域的大鼠被送往 MA 区域，分别停留 0 天、10 天和 20 天。对大鼠的PAP、血常规和计算机断层扫描心肌灌注指数进行测量：结果：与 MA 组相比，HA 组体重下降（P结果：与 MA 组相比，HA 组大鼠的体重下降（p 结论：从高体重回归到 MA 组大鼠的 PAP、血液参数和心肌微循环发生了显著变化：本研究为了解脱适应 HA 过程中的生理和病理机制提供了实验依据，为预防和治疗脱适应 HA 综合征提供了新的思路：在真实的高原环境中饲养了40只大鼠。要点：40 只大鼠在真实的高原环境中饲养，通过 CT 心肌灌注成像检测心肌微循环。未适应环境的大鼠的PAP先升高后降低。脱敏大鼠的心肌微循环出现高灌注变化。
Evaluation of pulmonary artery pressure, blood indices, and myocardial microcirculation in rats returning from high altitude to moderate altitude.
Background: To investigate changes in pulmonary artery pressure (PAP), blood indices, and myocardial microcirculation in rats returning from high altitude (HA) to moderate altitude (MA).
Methods: Forty 4-week-old male Sprague-Dawley rats were randomly divided into four groups with ten rats in each group. One group was transported to the MA area (MA-group), and the other three groups were transported to HA (HA-group-A, HA-group-B, and HA-group-C). After 28 weeks of age, the rats from the HA area were transported to the MA area for 0 days, 10 days, and 20 days, respectively. PAP, routine blood tests, and computed tomography myocardial perfusion indices were measured.
Results: Compared with the MA-group, the body weight of HA-groups decreased (p < 0.05), and PAP in HA-group-A and HA-group-B increased (p < 0.05). In the HA groups, PAP initially increased and then decreased. Compared with the MA-group, red blood cells (RBC), hemoglobin (HGB), and hematocrit (HCT) of rats in HA-group-A increased (p < 0.05). Compared with the HA-group-A, RBC, HGB, and HCT of HA-group-B gradually decreased (p < 0.05) while MCV decreased (p < 0.05), and PLT of HA-group-C increased (p < 0.05). Compared with the MA group, blood flow (BF) and blood volume (BV) of the HA-group-A decreased (p < 0.05). Compared with the HA-group-A, TTP increased first and then decreased (p < 0.05), and BF and BV increased gradually (p < 0.05). Pathological results showed that myocardial fiber arrangement was disordered, and cell space widened in the HA group.
Conclusion: PAP, blood parameters, and myocardial microcirculation in rats returning from high to MA exhibited significant changes.
Relevance statement: This study provides an experimental basis for understanding the physiological and pathological mechanisms during the process of deacclimatization to HA and offers new insights for the prevention and treatment of deacclimatization to HA syndrome.
Key points: Forty rats were raised in a real plateau environment. Myocardial microcirculation was detected by CT myocardial perfusion imaging. The PAP of the unacclimated rats increased first and then decreased. The myocardial microcirculation of the deacclimated rats showed hyperperfusion changes.
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