Zhi Zhang, Chenghao Li, Qian Zheng, Bing Shi, Renkai Liu
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引用次数: 0
摘要
目的研究单侧唇腭裂（UCLP）患者上颌正畸治疗时不同牙槽骨移植位置在咬合力加载下的生物力学效应：方法：在上颌正畸治疗过程中，对 8 个植骨模型施加咬合力，采用有限元分析法更准确地模拟临床情况。分析了上颌前突、扩张以及联合前突和扩张时的位移和 von Mises 应力模式：结果：与非植骨模型相比，7 个植骨模型在上颌牵拉和扩张过程中，非左侧地标的水平位移明显较小。此外，上1/3和中1/3的齿槽裂骨在上颌前伸和后伸时表现出更大的不对称位移和应力：本研究强调了在对 UCLP 患者的正畸疗法进行有限元研究时考虑咬合力的必要性。上1/3和中1/3植骨条件可能需要二次植骨补充，以确保上颌正畸治疗的有效性。
Finite element analysis of maxillary orthodontic therapies with variable alveolar bone grafts under occlusal forces in patient with unilateral cleft lip and palate.
Objective: To investigate the biomechanical effects of maxillary orthodontic treatment on different alveolar bone grafting positions loaded with occlusal forces in an unilateral cleft lip and palate (UCLP) patient.
Methods: Finite element analysis was employed to simulate clinical scenarios more accurately by loading with occlusal forces on 8 bone-grafted models during maxillary orthodontic treatment. Displacement and von Mises stress pattern during maxillary protraction, expansion, and combined protraction and expansion were analyzed.
Results: The seven bone-grafted models exhibited significantly smaller horizontal displacements at the non-cleft side landmarks during maxillary protraction and expansion compared to non-bone grafted models. Additionally, alveolar cleft bone grafted in the upper 1/3 and middle 1/3 exhibited greater asymmetry displacement and stress under maxillary protraction and expansion.
Conclusion: The study highlights the necessity of considering occlusal forces in finite element study on orthodontic therapies for UCLP patients. The upper 1/3 and middle 1/3 bone graft conditions may require secondary bone graft supplementation to ensure the effectiveness of maxillary orthodontic treatment.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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