{"title":"利用新型 Zn/Bi 双金属有机框架衍生 ZnO-Bi2O3 异质结传感平台高灵敏检测电子烟中的 CP 型合成大麻素。","authors":"Haiou Chen, Ying He, Shimeng Duan, Anyun Xu, Meng Li, Yanming Ren, Ruilin Zhang, Xiangjun Yang, Shixiong Wang, Huiping Bai","doi":"10.1007/s00604-024-06832-0","DOIUrl":null,"url":null,"abstract":"<div><p>Synthetic cannabinoids (SCs), often masqueraded in “e-cigarettes,” are novel popular psychoactive substances with diverse structures and complex material compositions, making their detection more challenging for prompt intervention. Herein, a novel electrochemical sensing platform based on Zn/Bi bimetallic organic framework-derived ZnO-Bi<sub>2</sub>O<sub>3</sub> heterojunctions was constructed for the detection of cyclohexanylphenol synthetic cannabinoids (CP-type SCs: CP47,497 and CP55,940). The sensing characteristics of ZnO-Bi<sub>2</sub>O<sub>3</sub> were studied under various conditions, including solvent composition, molar ratio of metal, and calcination temperature. The optimized ZnO-Bi<sub>2</sub>O<sub>3</sub> heterojunction exhibited a larger surface area, more active sites, and stronger stability, conducive to enhanced electrochemical catalytic performance. Under optimal conditions, a ZnO-Bi<sub>2</sub>O<sub>3</sub> modified screen-printed electrode (ZnO-Bi<sub>2</sub>O<sub>3</sub>/SPE) showed good linear responses toward CP47,497 and CP55,940 within the concentration ranges 7 × 10<sup>−9</sup> ~ 5 × 10<sup>−6</sup> M and 1 × 10<sup>−9</sup> ~ 5 × 10<sup>−6</sup> M, with detection limits of 2.3 × 10<sup>−9</sup> M and 3.3 × 10<sup>−10</sup> M, respectively. The sensor also depicted excellent reliability and can be used for on-site electrochemical detection of target objects in e-cigarettes with high recovery. Finally, the electrochemical oxidation mechanisms of CP47,497 and CP55,940 were studied for the first time, and electrochemical fingerprints of CP-type SCs were speculated.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"191 12","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly-sensitive detection of CP-type synthetic cannabinoids from e-cigarettes by a novel Zn/Bi bimetallic organic framework-derived ZnO-Bi2O3 heterojunctions sensing platform\",\"authors\":\"Haiou Chen, Ying He, Shimeng Duan, Anyun Xu, Meng Li, Yanming Ren, Ruilin Zhang, Xiangjun Yang, Shixiong Wang, Huiping Bai\",\"doi\":\"10.1007/s00604-024-06832-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Synthetic cannabinoids (SCs), often masqueraded in “e-cigarettes,” are novel popular psychoactive substances with diverse structures and complex material compositions, making their detection more challenging for prompt intervention. Herein, a novel electrochemical sensing platform based on Zn/Bi bimetallic organic framework-derived ZnO-Bi<sub>2</sub>O<sub>3</sub> heterojunctions was constructed for the detection of cyclohexanylphenol synthetic cannabinoids (CP-type SCs: CP47,497 and CP55,940). The sensing characteristics of ZnO-Bi<sub>2</sub>O<sub>3</sub> were studied under various conditions, including solvent composition, molar ratio of metal, and calcination temperature. The optimized ZnO-Bi<sub>2</sub>O<sub>3</sub> heterojunction exhibited a larger surface area, more active sites, and stronger stability, conducive to enhanced electrochemical catalytic performance. Under optimal conditions, a ZnO-Bi<sub>2</sub>O<sub>3</sub> modified screen-printed electrode (ZnO-Bi<sub>2</sub>O<sub>3</sub>/SPE) showed good linear responses toward CP47,497 and CP55,940 within the concentration ranges 7 × 10<sup>−9</sup> ~ 5 × 10<sup>−6</sup> M and 1 × 10<sup>−9</sup> ~ 5 × 10<sup>−6</sup> M, with detection limits of 2.3 × 10<sup>−9</sup> M and 3.3 × 10<sup>−10</sup> M, respectively. The sensor also depicted excellent reliability and can be used for on-site electrochemical detection of target objects in e-cigarettes with high recovery. Finally, the electrochemical oxidation mechanisms of CP47,497 and CP55,940 were studied for the first time, and electrochemical fingerprints of CP-type SCs were speculated.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"191 12\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-024-06832-0\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-024-06832-0","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Highly-sensitive detection of CP-type synthetic cannabinoids from e-cigarettes by a novel Zn/Bi bimetallic organic framework-derived ZnO-Bi2O3 heterojunctions sensing platform
Synthetic cannabinoids (SCs), often masqueraded in “e-cigarettes,” are novel popular psychoactive substances with diverse structures and complex material compositions, making their detection more challenging for prompt intervention. Herein, a novel electrochemical sensing platform based on Zn/Bi bimetallic organic framework-derived ZnO-Bi2O3 heterojunctions was constructed for the detection of cyclohexanylphenol synthetic cannabinoids (CP-type SCs: CP47,497 and CP55,940). The sensing characteristics of ZnO-Bi2O3 were studied under various conditions, including solvent composition, molar ratio of metal, and calcination temperature. The optimized ZnO-Bi2O3 heterojunction exhibited a larger surface area, more active sites, and stronger stability, conducive to enhanced electrochemical catalytic performance. Under optimal conditions, a ZnO-Bi2O3 modified screen-printed electrode (ZnO-Bi2O3/SPE) showed good linear responses toward CP47,497 and CP55,940 within the concentration ranges 7 × 10−9 ~ 5 × 10−6 M and 1 × 10−9 ~ 5 × 10−6 M, with detection limits of 2.3 × 10−9 M and 3.3 × 10−10 M, respectively. The sensor also depicted excellent reliability and can be used for on-site electrochemical detection of target objects in e-cigarettes with high recovery. Finally, the electrochemical oxidation mechanisms of CP47,497 and CP55,940 were studied for the first time, and electrochemical fingerprints of CP-type SCs were speculated.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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