古蛋白质组学揭示百万年前化石的奥秘

IF 81.3 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2024-11-19 DOI:10.1038/s41580-024-00803-2

Ryan Sinclair Paterson, Palesa Petunia Madupe, Enrico Cappellini

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引用次数: 0

摘要

目前已经确定的是，远古蛋白质的存续时间和信息量远远超过 DNA。因此，对古蛋白质进行测序是目前唯一可行的方法，可用于检索解决数百万年前消失的脊椎动物物种之间进化关系所需的遗传数据。古蛋白质能够以超越古 DNA 的时间尺度提供系统发育信息。因此，古蛋白质组学可以提供宝贵的进化见解，包括对人类进化的见解。

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Paleoproteomics sheds light on million-year-old fossils

It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequencing of ancient proteins is currently the only viable methodology for retrieving the genetic data required to resolve evolutionary relations between vertebrate species that disappeared millions of years ago. Ancient proteins can provide phylogenetic information at a timescale that supersedes ancient DNA. Paleoproteomics could thus provide invaluable evolutionary insights, including into human evolution.

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.