慢性缺氧对心脏的保护作用涉及抑制线粒体通透性转换孔的开放。

IF 1.9 4区医学 Q3 PHYSIOLOGY

Physiological research Pub Date : 2024-11-19 DOI:10.33549/physiolres.935427

P Alanova, L Alan, J Neckar, B Ostadal, F Kolar

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引用次数: 0

摘要

本研究旨在探讨线粒体通透性转换孔（mPTP）在慢性持续缺氧（CH）对急性心肌缺血再灌注（I/R）损伤的心脏保护作用中的潜在作用。成年雄性 Wistar 大鼠适应 CH 3 周，而其对照组则在常氧条件下饲养。随后，对它们进行I/R损伤，同时给予mPTP抑制剂环孢素A（CsA）。测定了心肌梗死的大小以及缺血和再灌注心律失常的发生率。我们的研究结果表明，与相应的对照组相比，适应 CH 和服用 CsA 可缩小心肌梗死面积。然而，服用 CsA 并没有扩大 CH 的有益作用，这表明抑制 mPTP 开放是 CH 的保护性特征之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardioprotective Effect of Chronic Hypoxia Involves Inhibition of Mitochondrial Permeability Transition Pore Opening.

The aim of the study was to examine the potential role of mitochondrial permeability transition pore (mPTP) in the cardioprotective effect of chronic continuous hypoxia (CH) against acute myocardial ischemia/reperfusion (I/R) injury. Adult male Wistar rats were adapted to CH for 3 weeks, while their controls were kept under normoxic conditions. Subsequently, they were subjected to I/R insult while being administered with mPTP inhibitor, cyclosporin A (CsA). Infarct size and incidence of ischemic and reperfusion arrhythmias were determined. Our results showed that adaptation to CH as well as CsA administration reduced myocardial infarct size in comparison to the corresponding control groups. However, administration of CsA did not amplify the beneficial effect of CH, suggesting that inhibition of mPTP opening contributes to the protective character of CH.

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来源期刊

Physiological research 医学-生理学

CiteScore

4.00

自引率

4.80%

发文量

108

审稿时长

3 months

期刊介绍： Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology. Authors can submit original, previously unpublished research articles, review articles, rapid or short communications. Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process. The articles are available in full versions as pdf files beginning with volume 40, 1991. The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.