R Ben Salah, M Boudaya, S Fendri, R Marrekchi, Z Bahloul, K Jamoussi
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Hyperhomocysteinemia prevalence among patients with venous thromboembolism.
Aims: The objectives of this study were to determine the plasma homocysteine (Hcy) levels and the prevalence of Hyperhomocysteinemia (HHC) in a group of Tunisian patients with deep vein thrombosis (DVT) by comparing it with healthy controls.
Methods: it was an observational case-control study including patients hospitalized for the management of unprovoked DVT. For each subject, a routine biochemical assay was conducted, including plasma homocysteine measurement and determination of vitamin B12 and B9 levels, as these vitamins are essential for assessing hyperhomocysteinemia in DVT patients due to their role in regulating homocysteine.
Results: We observed an increased mean plasma Hcy level compared to controls and the prevalence of Hyperhomocysteinemia 61.7% against 4% in the control subjects. The risk of developing DVT with HHC is 3.54.
Conclusion: Our study found that homocysteine levels were higher in patients with DVT than in controls.
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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