Recent Advances of C-S Coupling Reaction of (Hetero)Arenes by C-H Functionalization.

Organic sulfur compounds encompass a vast and diverse variety of species that possess unique biological activity due to the presence of sulfur atoms or sulfur-containing functional groups. These compounds are widely present in natural products, pharmaceuticals, agricultural chemicals, and functional materials. In recent years, numerous sulfur-containing compounds such as thiols, thioethers, disulfides, thiourea, dimethyl sulfoxide, sulfonates and their derivatives, as well as sulfur-containing inorganic compounds, have been utilized as coupling agents to synthesize (hetero)aryl sulfides via C-H Functionalization. These novel transformations provide effective methods for constructing C-S bond of (hetero)arenes, while also expanding the scope of (hetero)aryl sulfides with the potential biological activity. Therefore, the synthesis of aryl sulfides through C-H bond functionalization has attracted widespread attention. This review mainly focuses on the construction of (hetero)aryl sulfides via C-H bond functionalization since 2015. We hope this review offers a useful conceptual overview and inspires further advancements in the efficient construction of C-S bonds.