机械化学促进银催化杂环戊烯的直接 H/D 交换。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-19 DOI:10.1039/d4ob01581a

Yun Jia, Zhi-Jiang Jiang, Jiawei Han, Kenan Wang, Si-Han Xu, Jian-Fei Bai, Jia Chen, Yifeng Han, Zhanghua Gao

{"title":"机械化学促进银催化杂环戊烯的直接 H/D 交换。","authors":"Yun Jia, Zhi-Jiang Jiang, Jiawei Han, Kenan Wang, Si-Han Xu, Jian-Fei Bai, Jia Chen, Yifeng Han, Zhanghua Gao","doi":"10.1039/d4ob01581a","DOIUrl":null,"url":null,"abstract":"Despite recent advances in H/D exchange, the effective deuteration of polyarenes remains challenging, due to their insolubility and hydrophobicity. This study presents a concept proofing of a mechanochemically facilitated direct H/D exchange. The silver-catalyzed deuteration of heteroarenes was promoted smoothly within 99 minutes of grinding, with heavy water as the deuterium source.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanochemically facilitated silver-catalyzed direct H/D exchange on heteroarenes.\",\"authors\":\"Yun Jia, Zhi-Jiang Jiang, Jiawei Han, Kenan Wang, Si-Han Xu, Jian-Fei Bai, Jia Chen, Yifeng Han, Zhanghua Gao\",\"doi\":\"10.1039/d4ob01581a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Despite recent advances in H/D exchange, the effective deuteration of polyarenes remains challenging, due to their insolubility and hydrophobicity. This study presents a concept proofing of a mechanochemically facilitated direct H/D exchange. The silver-catalyzed deuteration of heteroarenes was promoted smoothly within 99 minutes of grinding, with heavy water as the deuterium source.\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d4ob01581a\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01581a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

尽管最近在 H/D 交换方面取得了进展，但由于聚烯烃的不溶性和疏水性，对其进行有效脱氘仍然具有挑战性。本研究提出了一种机械化学促进直接 H/D 交换的概念验证。以重水为氘源，银催化的杂多烯烃氘交换在研磨 99 分钟内顺利进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mechanochemically facilitated silver-catalyzed direct H/D exchange on heteroarenes.

Despite recent advances in H/D exchange, the effective deuteration of polyarenes remains challenging, due to their insolubility and hydrophobicity. This study presents a concept proofing of a mechanochemically facilitated direct H/D exchange. The silver-catalyzed deuteration of heteroarenes was promoted smoothly within 99 minutes of grinding, with heavy water as the deuterium source.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.