脱髓鞘疾病患者神经脊髓炎视网膜谱系障碍的患病率、发病率和临床评估

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2024-11-01 DOI:10.1016/j.nrl.2022.06.004

M.A. Mireles-Ramírez , I.E. Velázquez-Brizuela , N. Sánchez-Rosales , Y. Márquez-Pedroza , M.R. Hernandez-Preciado , G. Gabriel Ortiz

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引用次数: 0

摘要

背景视神经脊髓炎谱系障碍（NMOSD）的特征是视神经炎和横贯性脊髓炎反复发作。本研究旨在确定墨西哥西部因脱髓鞘疾病而接受治疗的人群中 NMOSD 的发病率和流行率及其临床特征。材料与方法在墨西哥社会保障局（IMSS）国家西部医疗中心（CMNO）专科医院（西班牙文缩写为 UMAE-HE）亚专科医疗单位的神经内科开展了一项描述性回顾研究。对墨西哥哈利斯科州 2019 年诊断为 NMOSD 的所有患者的电子档案进行了审查。发病率为 0.71/100000（CI 0.60-0.85），患病率为 1.09/100000（CI 0.84-1.42）。女性占 79.3%，男性占 20.6%（P = 0.01）。所有患者（100%）均出现抗喹呤-4 免疫球蛋白 G，89.6% 的患者抗喹呤-4 血清阳性（CI 82.6-94.9）。100%的患者接受了磁共振成像检查，其中34.4%正常，65.5%（38例）异常，表现为非特异性皮层下病变（P = 0.04）。58.6%的患者最初的临床表现为视神经炎（ON），其中31.0%为双侧ON，20.7%为左侧ON，6.9%为右侧ON；26.0%为横贯性脊髓炎，10.3%为后遗区综合征（APS）等。

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The prevalence, incidence, and clinical assessment of neuromyelitis optica spectrum disorder in patients with demyelinating diseases

Background

Neuromyelitis optica spectrum disorder (NMOSD) is characterised by recurrent attacks of optic neuritis and transverse myelitis. The purpose of this work was to identify the incidence and prevalence of NMOSD and its clinical characteristics in the population treated for demyelinating diseases in Western Mexico.

Material and method

A descriptive, retrospective study was carried out in the Department of Neurology, at the Sub-specialty Medical Unit, Specialties Hospital (known by its Spanish abbreviation UMAE-HE), of the National Western Medical Center (CMNO), Mexican Institute of Social Security (IMSS). A review of the electronic files for all patients with a diagnosis of NMOSD in 2019, was carried out in the State of Jalisco, Mexico.

Results

Fifty-eight patients with NMOSD were included in the study. The incidence was 0.71/100 000 (CI 0.60-0.85) and the prevalence was 1.09/100 000 (CI 0.84-1.42). There were 79.3% women, and 20.6% were men (P = .01). All (100%) patients presented with anti-aquaporin-4 immunoglobulin G, and 89.6% showed seropositivity for anti-aquaporin-4 (CI 82.6-94.9). Magnetic resonance imaging was performed on 100% of patients, where 34.4% were normal, and 65.5% (38) abnormal, presenting with non-specific subcortical lesions (P = 0.04). The initial clinical presentation was optic neuritis (ON) in 58.6%; where 31.0% was bilateral ON, 20.7% was left ON, and 6.9% were right ON; transverse myelitis in 26.0%, area postrema syndrome (APS) in 10.3%, among others.

Conclusions

The incidence of NMOSD exceeds 0.71/100 000, the prevalence is low at 1.09/100 000, and NMOSD is predominantly found in women.

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.