使用具有两个切换流形的片断平滑矢量场的间歇性艾滋病治疗动力学

IF 1.8 3区 数学 Q1 MATHEMATICS, APPLIED
Tiago Carvalho , Jackson Cunha , Rodrigo Euzébio , Marco Florentino
{"title":"使用具有两个切换流形的片断平滑矢量场的间歇性艾滋病治疗动力学","authors":"Tiago Carvalho ,&nbsp;Jackson Cunha ,&nbsp;Rodrigo Euzébio ,&nbsp;Marco Florentino","doi":"10.1016/j.nonrwa.2024.104256","DOIUrl":null,"url":null,"abstract":"<div><div>In this paper we study the dynamics of a piecewise smooth vector field modeling an intermittent human immunodeficiency virus treatment where the patient is recurrently submitted and removed from drug administration. In fact, the protocol says that the drugs are administered when the level of CD4<span><math><msup><mrow></mrow><mrow><mo>+</mo></mrow></msup></math></span> T defense cells is smaller than a fixed number <span><math><msubsup><mrow><mi>C</mi></mrow><mrow><mi>o</mi><mi>f</mi><mi>f</mi></mrow><mrow><mi>T</mi></mrow></msubsup></math></span>. When the level of CD4<span><math><msup><mrow></mrow><mrow><mo>+</mo></mrow></msup></math></span> T cells is greater than a fixed number <span><math><msubsup><mrow><mi>C</mi></mrow><mrow><mi>o</mi><mi>n</mi></mrow><mrow><mi>T</mi></mrow></msubsup></math></span> (distinct from <span><math><msubsup><mrow><mi>C</mi></mrow><mrow><mi>o</mi><mi>f</mi><mi>f</mi></mrow><mrow><mi>T</mi></mrow></msubsup></math></span>) the drugs are not administered to provide a better recovery from side effects. Moreover, the orbits of the piecewise smooth vector fields are trapped within a compact set, which proves that the protocol controls the disease.</div></div>","PeriodicalId":49745,"journal":{"name":"Nonlinear Analysis-Real World Applications","volume":"82 ","pages":"Article 104256"},"PeriodicalIF":1.8000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dynamics of an intermittent HIV treatment using piecewise smooth vector fields with two switching manifolds\",\"authors\":\"Tiago Carvalho ,&nbsp;Jackson Cunha ,&nbsp;Rodrigo Euzébio ,&nbsp;Marco Florentino\",\"doi\":\"10.1016/j.nonrwa.2024.104256\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In this paper we study the dynamics of a piecewise smooth vector field modeling an intermittent human immunodeficiency virus treatment where the patient is recurrently submitted and removed from drug administration. In fact, the protocol says that the drugs are administered when the level of CD4<span><math><msup><mrow></mrow><mrow><mo>+</mo></mrow></msup></math></span> T defense cells is smaller than a fixed number <span><math><msubsup><mrow><mi>C</mi></mrow><mrow><mi>o</mi><mi>f</mi><mi>f</mi></mrow><mrow><mi>T</mi></mrow></msubsup></math></span>. When the level of CD4<span><math><msup><mrow></mrow><mrow><mo>+</mo></mrow></msup></math></span> T cells is greater than a fixed number <span><math><msubsup><mrow><mi>C</mi></mrow><mrow><mi>o</mi><mi>n</mi></mrow><mrow><mi>T</mi></mrow></msubsup></math></span> (distinct from <span><math><msubsup><mrow><mi>C</mi></mrow><mrow><mi>o</mi><mi>f</mi><mi>f</mi></mrow><mrow><mi>T</mi></mrow></msubsup></math></span>) the drugs are not administered to provide a better recovery from side effects. Moreover, the orbits of the piecewise smooth vector fields are trapped within a compact set, which proves that the protocol controls the disease.</div></div>\",\"PeriodicalId\":49745,\"journal\":{\"name\":\"Nonlinear Analysis-Real World Applications\",\"volume\":\"82 \",\"pages\":\"Article 104256\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-11-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nonlinear Analysis-Real World Applications\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1468121824001950\",\"RegionNum\":3,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATHEMATICS, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nonlinear Analysis-Real World Applications","FirstCategoryId":"100","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1468121824001950","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATHEMATICS, APPLIED","Score":null,"Total":0}
引用次数: 0

摘要

在本文中,我们研究了一个片断平滑矢量场的动力学模型,它模拟了一种间歇性人类免疫缺陷病毒治疗方法,在这种治疗方法中,病人会反复服药和停药。事实上,治疗方案规定,当 CD4+ T 防御细胞的水平小于一个固定的数字 CoffT 时,就会给药。当 CD4+ T 细胞的水平大于一个固定的数字 ConT(与 CoffT 不同)时,则不用药,以便更好地从副作用中恢复过来。此外,片断平滑矢量场的轨道被困在一个紧凑集合内,这证明该方案能控制疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamics of an intermittent HIV treatment using piecewise smooth vector fields with two switching manifolds
In this paper we study the dynamics of a piecewise smooth vector field modeling an intermittent human immunodeficiency virus treatment where the patient is recurrently submitted and removed from drug administration. In fact, the protocol says that the drugs are administered when the level of CD4+ T defense cells is smaller than a fixed number CoffT. When the level of CD4+ T cells is greater than a fixed number ConT (distinct from CoffT) the drugs are not administered to provide a better recovery from side effects. Moreover, the orbits of the piecewise smooth vector fields are trapped within a compact set, which proves that the protocol controls the disease.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.80
自引率
5.00%
发文量
176
审稿时长
59 days
期刊介绍: Nonlinear Analysis: Real World Applications welcomes all research articles of the highest quality with special emphasis on applying techniques of nonlinear analysis to model and to treat nonlinear phenomena with which nature confronts us. Coverage of applications includes any branch of science and technology such as solid and fluid mechanics, material science, mathematical biology and chemistry, control theory, and inverse problems. The aim of Nonlinear Analysis: Real World Applications is to publish articles which are predominantly devoted to employing methods and techniques from analysis, including partial differential equations, functional analysis, dynamical systems and evolution equations, calculus of variations, and bifurcations theory.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信